Publications by authors named "Nistor T"
Article Synopsis
- - Hashimoto's thyroiditis (HT) is a significant autoimmune thyroid disease where patients often present with asthenia (fatigue), presenting challenges in differentiating it from other conditions; this study aimed to analyze the relationship between HT and asthenia in newly diagnosed patients.
- - Conducted between July 2022 and July 2023 across multiple university hospitals, the study included 120 patients, divided into an asthenia group (49.2%) and a non-asthenia group, discovering that asthenia was linked to a higher incidence of headaches and hypothyroidism but thyroid function tests were similar between both groups.
- - The findings suggest that asthenia may not be a strong indicator of thyroid dysfunction
Article Synopsis
- A less-than-total thyroidectomy reduces the risk of complications like hypothyroidism and nerve injury, but may necessitate "redo" surgery if unexpected cancer or disease progression is found post-op.
- The review analyzed recent English-language studies on redo thyroid surgeries from 2020 to 2024, focusing on various surgical techniques and complications.
- Findings highlighted the rise in robotic-assisted surgeries and the need for more comprehensive studies to improve decision-making and risk assessment for redo interventions.
Article Synopsis
- Non-functioning adrenal incidentalomas (NFAIs) are associated with a higher risk of glucose profile issues, especially type 2 diabetes mellitus (T2DM), though clear links to Cushing's syndrome aren't fully established.
- A comprehensive literature review analyzed 37 studies involving over 17,000 individuals, finding T2DM prevalence in NFAIs with mild autonomous cortisol secretion (MACS) ranged from 12% to 44%, with some studies showing rates as high as 45.2%.
- Comparisons between NFAIs and non-tumor controls indicated increased T2DM rates in NFAIs, and while some studies examined Cushing's syndrome, results regarding glucose profile anomalies were inconsistent.
Article Synopsis
- - Analysis focused on three key aspects of pancreas involvement in primary hyperparathyroidism (PHP): hypercalcemia-induced pancreatitis (HCa-P), MEN1-related neuroendocrine tumors (NETs), and insulin resistance, utilizing studies from PubMed between January 2020 and January 2024.
- - Findings showed that HCa-P had links to NETs and pancreatitis, with case reports revealing instances in pregnant individuals and cases of parathyroid carcinoma; MEN1-related studies indicated a high recurrence rate after surgery and significant associations among PHP and pancreatic NETs.
- - Insulin resistance analysis indicated that about one-third of adults could be prediabetic, with a notable correlation between serum calcium levels and insulin resistance
Background: The modern management of phenylketonuria (PKU) consists of generalized newborn screening (NBS) for hyperphenylalaninemia (HPA), confirmation of HPA in children detected in the NBS, introduction of dietary treatment in the first weeks of life, followed by monitoring the treatment of PKU for decades to maintain phenylalaninemia within the limits that will not affect the brain. The present study aimed to evaluate the usefulness of two chromatographic methodologies for determination of plasma Phe level in the routine management of PKU: the two dimensional thin layer chromatography (2D - TLC) and the high performance liquid chromatography (HPLC) procedures, respectively.
Material And Methods: Samples of blood from 23 children with HPA detected by neonatal screening or with confirmed PKU who received treatment by low-Phe diet were analyzed to estimate the plasma Phe level by the two chromatographic procedures.
Objective: To compare two chromatographic methodologies for determination of plasma phenylalanine (Phe) and their usefulness for diagnosing hyperphenylalaninemia (HPA) and phenylketonuria (PKU).
Methods: The plasma amino acids were isolated and concentrated from blood collected from infants with HPA detected by newborn screening. The plasma Phe was determined in parallel by HPLC and by image-densitometry of 2D-TLC plates.
When compared with values recorded in 14 control subjects, the 15 overweight patients with type 2 diabetes displayed significantly increased activities of serum alanineaminotransferase (172% of mean values in controls), gamma-glutamyltransferase (253%) and cholinesterase (139%). A much wider dispersion of individual values for the two firstly mentioned enzymes was however noted so that their correlation with serum triglycerides levels were weaker (r = 0.373; p < 0.
View Article and Find Full Text PDFThe regional incidence of 21-hydroxylase deficiency, its mutational spectrum and the correlation of genotype and phenotype has been studied by European, American and Latin-American groups. However, little information is known about the molecular background of the disease in patients from Central-Eastern Europe. The present study aimed to genotype a group of patients from Transylvania, the north-western part of Romania, in order to gain some insight into the molecular pattern and the genotype-phenotype correlation of congenital adrenal hyperplasia (CAH) in this region.
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