Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia.

The cardioprotective effect of cardioplegic solution based on histidine-containing dipeptides was evaluated on isolated rat heart under conditions of hyporthermia and long ischemia. The use of natural dipeptides in cardioplegic solutions promoted an increase in the buffer capacity of myocardial cells and creation of an additional anti-ischemic effect under conditions of long ischemia and hypothermia.

[The differential diagnosis of anthrax in man].

The paper reports group cases of the disease running as anthrax. The disease was not identified etiologically. The authors hold that it is important to make differential diagnosis of anthrax with necrobacillosis, pasteurellosis and contact pustular viral dermatitis.

[The effect of anesthesia on the neurohumoral regulation system and water-electrolyte balance during aortocoronary bypass].

Two methods of multicomponent general anesthesia distinct in the analgetic agent used to ensure analgesia have been compared. In group I (6 patients) analgesia was ensured by fentanyl at a dose of 10 micrograms/(kg/min), in group II (7 patients) it was ensured by pyritramide (dipidolor) at a dose of 2 mg/kg for the whole operative period. The study has shown that during aortocoronary bypass surgery in patients with ischemic heart disease analgesia is better ensured by pyritramide than by fentanyl administration.

[Study of peripheral blood circulation during continuous and pulsatile perfusion based on the data of transcutaneous pO2 and pCO2 monitoring].

The study was performed on 22 patients with congenital heart valve defects after hypothermic cardiopulmonary bypass surgery. Transcutaneous and arterial pO2 and pCO2 have been measured at different stages of investigation. Nonpulsatile flow was applied to 10 patients and pulsatile flow--to 12 patients.

[Electrocardiographic changes in leptospirosis].

The study involved 239 ECGs recorded in acute period of various leptospirosis forms. In 86.2% of cases there were changes evidencing impairment of neuromuscular system and atrial (76.

[Non-invasive diagnosis of the degree of aortic coarctation].

Examined were 42 patients with aortal coarctation at the age of from 6 to 35 years. The differences in hemodynamics, microcirculation and oxygen regimen of tissues depending on the degree of aortal coarctation were revealed. To diagnose the degree of aortostenosis, it is suggested to use the transcutaneous monitoring of PO2 distally to the site of coarctation.

[Tissue oxygen metabolism, hemodynamics and microcirculation in vasorenal hypertension in patients with different types of blood circulation].

The authors examined 68 patients with vasorenal hypertension (VRH). In hyperkinetic type of VRH, the tissue hypoxia is caused by the increase in the cardiac index and rate of blood flow, changes in the microcirculation; in hypokinetic type--by decrease in the cardiac index, sharp increase in the specific peripheral vascular resistance and pronounced changes in all the links of microcirculatory channel as well is observed. Timely correction of the hyperkinetic type of VRH in patients leads to normalization of hemodynamics and elimination of tissue hypoxia.

[Etiological structure and clinical epidemiological characteristics of Leptospira infection in Rostov Province based on data from therapeutic institutions from 1960 to 1983].

Changes in communal conditions, in economy, as well as in ecology and fauna, which took place in Rostov Province during the last decade (1973-1983) determined shifts in the etiological structure of Leptospira infection and in its course. The study revealed an increase in morbidity caused by L. icterohaemorrhagiae (up to 61%) and L.

[Acid-base state and the electrolyte balance of young infants in the immediate postoperative period after radical correction of an interventricular septal defect under artificial circulation].

Acid-base equilibrium and electrolyte balance were studied in 80 infants in the immediate postoperative period after surgery for ventricular septal defect under conditions of extracorporeal circulation. Decompensated metabolic alkalosis was the most characteristic disorder of acid-base equillibrium in patients with an uncomplicated postoperative period, whereas decompensated respiratory alkalosis and metabolic acidosis were characteristic of patients with compensated and decompensated forms of cardiac insufficiency. Plasma hypokaliemia and hypochloremia attended by intracellular retention of sodium were typical disorders of the electrolyte balance in all forms of changes in the acid-base equilibrium.