Nanoparticles and phototherapy combination as therapeutic alternative in prostate cancer: A scoping review.

Prostate cancer (CaP) is one of the most common types of cancers worldwide. Despite the existing surgical techniques, prostatectomy patients may experience tumor recurrence. In addition, castration-resistant cancers pose a challenge, especially given their lack of response to standard care.

Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis.

Background: An increased number of major histocompatibility complex (MHC) class II-positive cells (OX-6+ cells) were observed in the glomerulus and periglomerular interstitium during the course of anti-glomerular basement membrane (anti-GBM) crescentic glomerulonephritis (GN) in WKY rats. This study aimed to demonstrate that periglomerular OX-6+ cells are dendritic cells (DCs) and to clarify their roles in the pathogenesis of this GN.

Methods: Kidney sections were stained with the OX-6 and the rat DC marker OX-62 by immunohistochemistry, and periglomerular OX-6+ cells were observed by immunoelectron microscopy.

Molecular characterization of water-selective AQP (EbAQP4) in hagfish: insight into ancestral origin of AQP4.

Hagfish (Eptatretus burgeri) are agnathous and are the earliest vertebrates still in existence. Pavement cells adjacent to the mitochondria-rich cells show orthogonal arrays of particles (OAPs) in the gill of hagfish, a known ultrastructural morphology of aquaporin (AQP) in mammalian freeze-replica studies, suggesting that an AQP homolog exists in pavement cells. We therefore cloned water channels from hagfish gill and examined their molecular characteristics.

Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer.

Background: Investigated were effects of overexpression of interleukin-10 (IL-10) on the outcome and progression of crescentic glomerulonephritis in Wistar-Kyoto (WKY) rats.

Methods: Rats were singly or simultaneously injected with antiglomerular basement membrane (a-GBM) antibody and adenoviral vector encoding rat IL-10 (Ad-rIL-10) or LacZ (Ad-LacZ) (3 x 1010 pfu/rat) intravenously, and were sacrificed at day 7. Their kidneys and other organs were isolated and examined by histology and immunohistochemistry.

Lengthening the Achilles tendon for the treatment of diabetic plantar forefoot ulceration.

The accepted hallmarks of care for plantar forefoot ulceration are meticulous wound care, nutrition, management of infection, and non-weight bearing of the ulcerative area. Tendo-Achilles lengthening is crucial in healing these ulcerations when it is determined that the Achilles tendon is one of the main biomechanical stresses that led to the ulceration. The Silfverskiold test helps determine whether a percutaneous lengthening or gastrocnemius recession is called for.

Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue.

Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256. The aim of this study was to examine whether AVP, and other agents that increase cAMP levels, could stimulate the phosphorylation of AQP2 in intact rat renal tissue. Rat renal papillae were prelabeled with 32P and incubated with vehicle or drugs, and then AQP2 was immunoprecipitated.

Foot and ankle injuries related to rock climbing. The role of footwear.

Interest in rock climbing has grown dramatically over the past decade. Although considerable research has been conducted on upper-extremity injuries sustained during rock climbing, there has been no comprehensive evaluation of lower-extremity injuries and related biomechanics. The authors performed a retrospective investigation of rock-climbing injuries using a survey of 104 active rock climbers of varying levels of expertise.

Acute renal failure associated with Candida albicans infection.

A 16-year-old male with a long history of steroid-responsive nephrotic syndrome developed fever, abdominal pain, thrombocytopenia and acute renal failure. The clinical course and renal histology were similar to, but not typical of, haemolytic uremic syndrome. Positive cultures (throat, oesophagus, stool), an elevation in serum levels of specific antibody and fungal polysaccharide (1,3) beta-D-glucan and response to the antifungal therapy indicated an association between this syndrome and infection with Candida albicans.

Comparison of evoked spinal potentials by stimulation of the sciatic nerve and the spinal cord.

Spinal cord monitoring during surgery using evoked spinal potentials (ESP) is now popular. In cats, ESPs due to both sciatic nerve (SN-ESP) and spinal cord stimulation (SC-AESP and SC-DESP) were recorded from the epidural space. Both SN-ESP and SC-AESP were compared by parameter studies.