Publications by authors named "Nishanth N Nair"
Article Synopsis
- Vancomycin is an important last-resort antibiotic for treating Gram-positive infections, but it is ineffective against Gram-negative bacteria (GNB).
- A new derivative called VanNHdipi, created by altering vancomycin’s sugar component, shows up to 100 times greater effectiveness against vancomycin-resistant bacteria and also impacts cell wall and membrane integrity differently than vancomycin.
- VanNHdipi effectively inactivates metallo-β-lactamases (MBLs), resensitizing resistant bacteria to carbapenems, highlighting its potential in addressing antibiotic resistance.
