Publications by authors named "Nishant V Sangole"
Article Synopsis
- Tenecteplase is a crucial treatment for acute myocardial infarction, with both Metalyse(®) and a biosimilar called Elaxim(®) available in India.
- Research shows that Elaxim has less clot lysis activity and a different biochemical profile compared to Metalyse, including variations in glycosylation and purity.
- These differences raise concerns about whether Elaxim should be classified as a true "biosimilar" of Metalyse, especially without comparative clinical data to support its efficacy and safety.
Objectives: Angiotensin converting enzyme inhibitors (ACEIs) are known to possess different chemical structures, and change in structure of a drug can bring about change in its adverse drug reaction (ADR) profile. The study aims to observe the incidence and severity of ADRs between the di-carboxyl group containing ACEIs (d-ACEIs) versus phosphonate group containing ACEIs (p-ACEIs), in patients suffering from essential hypertension.
Materials And Methods: One hundred and twenty patients with essential hypertension were randomized into four groups receiving enalapril, lisinopril, ramipril, and fosinopril.