Sustained release of a model water-soluble compound via dry powder aerosolizable acetalated dextran microparticles.

To design and characterize aerosol microparticles (MP) to provide sustained release of the water-soluble compound sulforhodamine B (SRB) and achieve effective aerosol dispersion. Modulating the release of water-soluble compounds remains a challenge in pulmonary drug delivery. SRB and water made up an aqueous solution, while acetalated dextran (Ac-Dex) and isopropyl alcohol made up an organic solution.