Publications by authors named "Nishama De Silva Mohotti"
J Proteome Res
August 2024
Article Synopsis
- The study investigates how the lipid composition (lipidome) in the central nervous system changes during the processes of demyelination and remyelination in a mouse model called -iCKO-.
- Through mass spectrometry and longitudinal analysis over 24 weeks, researchers found unique lipid profiles for the brain and spinal cord, indicating different abilities to regenerate myelin.
- Notably, higher levels of specific lipids (plasmalogens) were found during early demyelination, and some lipids changed in response to a remyelinating drug, suggesting potential biomarkers for future research in this area.
