A Cross-Sectional Study on Neuropathic Pain Associated With Quality of Sleep in Spondylosis Patients.

Introduction: Neuropathic pain (NP) is common in spondylosis patients. Cervical and lumbar spondylosis are more common in the elderly population. Spondylosis patients also suffer from poor quality of sleep (QOS).

Functions of potassium channels blocked by low micromolar 4-aminopyridine in the crayfish nervous system.

4-aminopyridine (4-AP) is a potassium channel blocker that has been used to treat patients with multiple sclerosis and Lambert-Eaton disease. The concentration of this drug in the blood of patients was estimated to be in low or submicromolar range. Animal studies have shown that 4-AP at such low concentration selectively blocks a subset of channels in Kv1 or Kv3 families.

Domestic Violence During Pregnancy: Evaluating the Impact on Maternal and Perinatal Health-A Pilot Study in Uttar Pradesh.

Introduction: Domestic Violence [DV] is a global health problem of pandemic proportions. WHO identifies it as psychological, physical or sexual violence or threats of the same, in the premises of one's home. The perpetrator can be husband, intimate partner, friend or a family member.

Comprehending Optimality of Finger Flexor Tendon Pulley System Using Computational Analysis.

Existing prosthetic/orthotic designs are rarely based on kinetostatics of a biological finger, especially its tendon-pulley system (TPS). Whether a biological TPS is optimal for use as a reference, say for design purposes, and if so, in what sense, is also relatively unknown. We expect an optimal TPS to yield a high range of flexion while operating with lower tendon tension, bowstringing, and pulley stresses.

Integrated transcriptomic and proteomic analysis of microplasts derived from macrophage-conditioned medium-treated MCF-7 breast cancer cells.

Microplasts are large extracellular vesicles originating from migratory, invasive, and metastatic cancer cells. Here, to gain insight into the role of microplasts in cancer progression, we performed a proteomic and transcriptomic characterization of microplasts isolated from MCF-7 breast cancer cells treated with macrophage-conditioned medium. These cells were found to be viable, highly migratory, and metabolically active, indicating that microplasts derived from these cells are not apoptotic bodies.

Chronic exposure of humans to high level natural background radiation leads to robust expression of protective stress response proteins.

Understanding exposures to low doses of ionizing radiation are relevant since most environmental, diagnostic radiology and occupational exposures lie in this region. However, the molecular mechanisms that drive cellular responses at these doses, and the subsequent health outcomes, remain unclear. A local monazite-rich high level natural radiation area (HLNRA) in the state of Kerala on the south-west coast of Indian subcontinent show radiation doses extending from ≤ 1 to ≥ 45 mGy/y and thus, serve as a model resource to understand low dose mechanisms directly on healthy humans.

Comparative proteomic analysis of human peripheral blood mononuclear cells indicates adaptive response to low-dose radiation in individuals from high background radiation areas of Kerala.

There remain significant uncertainties in estimation of risks with low doses of radiation. The small coastal belt in the southwestern state of Kerala, India, extending from Neendakara in the south to Purakkad in the north is one of the most extensively studied high-level natural background radiation areas (HLNRAs) of the world to address these concerns. The natural radioactivity here is due to occurrence of monazite sand bearing placer deposits along the coastline.

Hand-Exoskeleton Assisted Progressive Neurorehabilitation using Impedance Adaptation based Challenge Level Adjustment Method.

This paper presents an underactuated design of a robotic hand exoskeleton and a challenge based neurorehabilitation strategy. The exoskeleton is designed to reproduce natural human fingertip paths during extension and grasping, keeping minimal kinematic complexity. It facilitates an impedance adaptation based trigged assistance control strategy by a switching between active non-assist and passive assistance modes.

Comparative Analysis of Apical Root Crack Propagation after Root Canal Preparation at Different Instrumentation Lengths Using ProTaper Universal, ProTaper Next and ProTaper Gold Rotary Files: An Study.

Aim: To compare the incidence of apical root crack formation after root canal preparation at different instrumentation lengths using ProTaper Universal (PTU), ProTaper Next (PTN) and ProTaper Gold (PTG) file systems.

Subjects And Methods: Eighty-four mandibular first premolars with single and straight root canal were mounted in resin block after simulating periodontal ligaments. 1-2 mm of root apex was exposed followed by sectioning of 1 mm of root tip for better stereomicroscopic visualization.

Gene expression of immediate early genes of AP-1 transcription factor in human peripheral blood mononuclear cells in response to ionizing radiation.

Ionizing radiation (IR) is considered ubiquitous in nature. The immediate early genes are considered the earliest nuclear targets of IR and are induced in the absence of de novo protein synthesis. Many of these genes encode transcription factors that constitute the first step in signal transduction to couple cytoplasmic effects with long-term cellular response.

Dynamic changes in the proteome of human peripheral blood mononuclear cells with low dose ionizing radiation.

Humans are continually exposed to ionizing radiation from natural as well as anthropogenic sources. Though biological effects of high dose radiation exposures have been well accepted, studies on low-to-moderate dose exposures (in the range of 50-500 mGy) have been strongly debated even as researchers continue to search for elusive 'radiation signatures' in humans. Proteins are considered as dynamic functional players that drive cellular responses.

A study on cortico-muscular coupling in finger motions for exoskeleton assisted neuro-rehabilitation.

In this paper our objective is to analyze the cortico-muscular coupling for hand finger motion and its possible use in the control of an exoskeleton based neurorehabilitation system for stroke sufferers. Cortical activity alone is often not sufficient to reliably control a device such as an exoskeleton and hence, our focus is to ascertain and analyze the connectivity between the motor cortex and forearm muscles, controlling the fingers, in terms of coherence between electroencephalogram (EEG) and electromyogram (EMG) signals. We have analyzed the signals separately for three different kinds of exercises consisting of passive motion of fingers using exoskeleton, active motion without any assistance, and motor imagery of the same movements.

A prospective study to assess the levels of interleukin-6 following administration of diclofenac, ketorolac and tramadol after surgical removal of lower third molars.

Introduction: The surgical removal of impacted third molars involves, trauma to soft and bony tissue and can result in considerable pain, swelling, and trismus. The greater the amount of tissue injury the greater is the amount of inflammation in the perisurgical region. Interleukin-6 (IL-6) is both a pro inflammatory and anti-inflammatory cytokine.

Virtual water trade and time scales for loss of water sustainability: a comparative regional analysis.

Assessment and policy design for sustainability in primary resources like arable land and water need to adopt long-term perspective; even small but persistent effects like net export of water may influence sustainability through irreversible losses. With growing consumption, this virtual water trade has become an important element in the water sustainability of a nation. We estimate and contrast the virtual (embedded) water trades of two populous nations, India and China, to present certain quantitative measures and time scales.

Comparative Study Between Two Flaps-Trapezoidal flap (TZF) and Ocshenbein-Leubke Flap (OLF) in Periapical Surgeries.

The ultimate goal in surgical endodontics is not only the eradication of periapical pathosis but also preservation of periodontal tissues using suitable surgical techniques. Treatment outcomes are no longer acceptable without considering the esthetic consequences of all involved dentoalveolar structures. It is critical that incisions and tissue elevations and reflections are performed in a way that facilitates healing by primary intention.