Superselective intra-arterial chemotherapy for advanced retinoblastoma complicated by metastatic disease.

We present a case of a child with unilateral group E retinoblastoma (according to the International Classification of Retinoblastoma) who received superselective intra-arterial chemotherapy as primary therapy. Although the tumor showed signs of regression, the patient developed orbital metastases requiring surgical excision and chemotherapy. Eventually the affected eye progressed to total retinal detachment and required enucleation.

Optic disc diameter increases during acute elevations of intraocular pressure.

Purpose: To evaluate optic nerve diameter changes in glaucomatous and nonglaucomatous eyes during transient elevation of intraocular pressure (IOP).

Methods: This prospective experimental study included 100 subjects: 38 with glaucoma and 62 without glaucoma. Elevation of IOP to an average of 64 mm Hg for less than 30 seconds was induced in one eye of all subjects by means of a modified LASIK suction ring.

Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients.

Purpose: To investigate relationships between acute intraocular pressure (IOP)-induced optic nerve head surface deformation and corneal hysteresis and thickness in glaucomatous and nonglaucomatous human eyes.

Methods: This was a prospective experimental study of 100 subjects (38 with glaucoma, 62 without glaucoma). Data collected included spherical equivalent, optic disc diameter, central corneal thickness (CCT), axial length, cylinder, Goldmann IOP, Pascal IOP, and ocular pulse amplitude and ocular response analyzer (ORA) measurements of corneal hysteresis (CH).

Visual field changes after transient elevation of intraocular pressure in eyes with and without glaucoma.

Purpose: To evaluate visual field (VF) changes in glaucomatous and nonglaucomatous eyes after transient elevation of intraocular pressure (IOP).

Design: Prospective experimental study.

Participants: One hundred subjects (38 with glaucoma, 62 glaucoma suspects and controls).

Higher-order aberrations of lenticular opacities.

Purpose: To measure and quantify higher-order aberrations induced by different types of lenticular opacities.

Setting: Department of Ophthalmology, University of Auckland, and Department of Ophthalmology, Auckland Public Hospital, Auckland, New Zealand.

Methods: Patients with lenticular opacities were recruited from outpatient clinics of a major tertiary referral center for ophthalmology.

Epithelial defect, diffuse lamellar keratitis, and epithelial ingrowth following post-LASIK epithelial toxicity.

This case reports an association between 2 uncommon flap complications in 1 eye related to epithelial toxicity and subsequent epithelial defect secondary to prolonged intraoperative exposure to topical anesthesia. A patient had hyperopic laser in situ keratomileusis (LASIK) for the correction of +2.75 +1.