Exploration of Phaeanthine: A Bisbenzylisoquinoline Alkaloid Induces Anticancer Effect in Cervical Cancer Cells Involving Mitochondria-Mediated Apoptosis.

Natural-product-based pharmacophores possess considerably more structural diversity, attractive physicochemical features, and relatively less toxicity than synthesized drug entities. In this context, our studies on phaeanthine, a bisbenzylisoquinoline alkaloid isolated from the rhizomes of (Lam) Hook.f & Thoms.

Screening of Musa balbisiana Colla. seeds for antidiabetic properties and isolation of apiforol, a potential lead, with antidiabetic activity.

Background: 'Phytonutrients' have been reported to exert an incredible impact on the healthcare system and offer medical benefits including the prevention or treatment of lifestyle-associated diseases. We chose one of the most common and important plant families, Musaceae, for our present study and explored its antidiabetic potential.

Results: Seeds of the edible fruits of Musa balbisiana Colla.

Antioxidant activity, phenolic-flavonoid content and high-performance liquid chromatography profiling of three different variants of seeds: A comparative study.

Background: The medicinally important phytochemicals present in seeds probably accounts for its wide use in traditional systems of medicines in India, like Ayurveda, Unani, and Siddha.

Aim: The aim of the study was to determine the antioxidant potential of three different geographical variants of seeds and to compare the phenolic profiling to know the effect of geographical variation in phenolic composition.

Materials And Methods: Total phenolic and flavonoid content of seeds were analyzed.

Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.

(-)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity.