Publications by authors named "Nisha Peter"
Article Synopsis
- Cdk1 activity is tightly regulated during different phases of the cell cycle, and recent findings suggest that both Cdk1 and the phosphatase PP2A:B55 display bistable behavior that affects mitotic transitions.
- The study used quantitative assays and mathematical modeling to show that the interplay between Cdk1 activation and PP2A:B55 inactivation results in hysteresis, meaning the response of the cell cycle can differ based on previous states.
- Notably, the research indicates that inhibiting both Wee1 and Greatwall kinases leads to a loss of cell-cycle memory, which could have therapeutic implications, especially in cancer treatment strategies.
Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activity and the phosphatases that control Greatwall kinase and its substrates are poorly understood.
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