BILATERAL PARACENTRAL ACUTE MIDDLE MACULOPATHY AFTER CARDIOPULMONARY BYPASS.

Purpose: To report the first two observations of bilateral paracentral acute middle maculopathy in the early postoperative period after cardiopulmonary bypass procedures.

Methods: Comprehensive ophthalmic examinations were performed, including best-corrected visual acuity, Humphrey visual field testing, dilated fundus examination, and optical coherence tomography.

Results: Two patients complained of unilateral vision loss after cardiac surgery involving cardiopulmonary bypass.

Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans.

Oculomotor synkinesis is the involuntary movement of the eyes or eyelids with a voluntary attempt at a different movement. The chemokine receptor CXCR4 and its ligand CXCL12 regulate oculomotor nerve development; mice with loss of either molecule have oculomotor synkinesis. In a consanguineous family with congenital ptosis and elevation of the ptotic eyelid with ipsilateral abduction, we identified a co-segregating homozygous missense variant (c.

Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease.

Importance: Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive neurodegenerative disease that primarily affects motor neurons. Recently, three causative genes have been implicated in both ALS and glaucoma. However, it is still uncertain whether patients with ALS have neurodegeneration in their retinas.

Diagnosis and management of opacified silicone intraocular lenses in patients with asteroid hyalosis.

Unlabelled: We analyzed 3 calcified silicone IOLs from 2 patients with a history of asteroid hyalosis. In both cases, posterior capsule opacification had been diagnosed and a laser capsulotomy performed before referral. Subsequently, both IOLs were exchanged with hydrophobic acrylic IOLs that were placed in the sulcus.

Update on the surgical management of idiopathic intracranial hypertension.

Idiopathic intracranial hypertension (IIH) is a disorder of elevated intracranial pressure due to an unknown cause. In most cases, IIH can be managed with medical therapy and weight reduction. Surgical treatment of IIH is reserved for patients who cannot tolerate medical therapy, are nonadherent to medical therapy, develop progressive symptoms despite maximal medical therapy, or present with fulminant visual loss.

Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension.

Purpose: Pulmonary arterial hypertension (PAH) is a progressive vascular disease that results in high mortality and morbidity in sickle cell disease (SCD) patients. PAH diagnosis is invasive via right heart catheterization, but manual measurements of the main pulmonary artery (PA) diameters from computed tomography (CT) have shown promise as noninvasive surrogate marker of PAH. The authors propose a semiautomated computer-assisted diagnostic (CAD) tool to quantify the main PA size from pulmonary CT angiography (CTA).

CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension.

This retrospective study investigates the potential of image analysis to quantify for the presence and extent of pulmonary hypertension secondary to sickle cell disease (SCD). A combination of fast marching and geodesic active contours level sets were employed to segment the pulmonary artery from smoothed CT-Angiography images from 16 SCD patients and 16 matching controls. An algorithm based on fast marching methods was used to compute the centerline of the segmented arteries to measure automatically the diameters of the pulmonary trunk and first branches of the pulmonary arteries.

The association between early outcome, health-related quality of life, and survival following elective open-heart surgery.

We investigated the impact of perioperative complications on patients' health-related quality of life (HRQL) and intermediate-term survival after cardiac surgery. Improved results for cardiac surgery are well demonstrated in low rates of operative mortality and morbidity. However, the association between perioperative morbid events, HRQL at 1 year, and survival is unclear.