Novelty in the gut: a review of the gastrointestinal manifestations of syphilis.

Syphilis is a systemic infection caused by the spirochete . It is transmitted during pregnancy or through sexual contact. Signs and symptoms vary depending on the clinical stage of the disease.

Insight into Single-Molecule Imaging Techniques for the Study of Prokaryotic Genome Maintenance.

Genome maintenance comprises a group of complex and interrelated processes crucial for preserving and safeguarding genetic information within all organisms. Key aspects of genome maintenance involve DNA replication, transcription, recombination, and repair. Improper regulation of these processes could cause genetic changes, potentially leading to antibiotic resistance in bacterial populations.

Atmospheric deposition of microplastics in an urban conglomerate near to the foothills of Indian Himalayas: Investigating the quantity, chemical character, possible sources and transport mechanisms.

The global apprehension regarding the ubiquitous presence of microplastics (MPs) and their associated health risks underscore a significant challenge. However, our understanding on the occurrence and characteristics of this emerging class of pollutants in the different environmental compartments remains limited. For instance, despite housing approximately 20-25% of the global population, the evidence of the atmospheric MPs in Indian Subcontinent is exceedingly rare.

Single-Molecule Fluorescence Imaging of DNA Replication Stalling at Sites of Nucleoprotein Complexes.

DNA replication in cells occurs on crowded and often damaged template DNA, forming potentially deleterious roadblocks to the progressing replication fork. Numerous tools have been developed to investigate the mechanisms of DNA replication and the fate of stalled replication forks. Here, we describe single-molecule fluorescence imaging methods to visualize processive DNA replication and replication fork stalling at site-specific nucleoprotein complexes.

RecF protein targeting to post-replication (daughter strand) gaps II: RecF interaction with replisomes.

The bacterial RecF, RecO, and RecR proteins are an epistasis group involved in loading RecA protein into post-replication gaps. However, the targeting mechanism that brings these proteins to appropriate gaps is unclear. Here, we propose that targeting may involve a direct interaction between RecF and DnaN.

Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase.

Genome duplication occurs while the template DNA is bound by numerous DNA-binding proteins. Each of these proteins act as potential roadblocks to the replication fork and can have deleterious effects on cells. In Escherichia coli, these roadblocks are displaced by the accessory helicase Rep, a DNA translocase and helicase that interacts with the replisome.

Mechanism of transcription modulation by the transcription-repair coupling factor.

Elongation by RNA polymerase is dynamically modulated by accessory factors. The transcription-repair coupling factor (TRCF) recognizes paused/stalled RNAPs and either rescues transcription or initiates transcription termination. Precisely how TRCFs choose to execute either outcome remains unclear.