GCTI-SN: Geometry-inspired chemical and tissue invariant stain normalization of microscopic medical images.

Stain normalization of microscopic images is the first pre-processing step in any computer-assisted automated diagnostic tool. This paper proposes Geometry-inspired Chemical-invariant and Tissue Invariant Stain Normalization method, namely GCTI-SN, for microscopic medical images. The proposed GCTI-SN method corrects for illumination variation, stain chemical, and stain quantity variation in a unified framework by exploiting the underlying color vector space's geometry.

Metronidazole Induced Encephalopathy.

Metronidazole is an antimicrobial used for the treatment of anaerobic bacterial and protozoal infections. Neurological toxicity due to metronidazole use has been a matter of concern and many case reports of neurotoxicity are being published. We report here a case of a 32 years old male chronic alcoholic with multiple liver abscesses and history of 6 weeks use of metronidazole presenting with multiple episodes of seizures, burning sensation of feet and altered sensorium.