Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.

Male infertility can result from impaired sperm motility caused by multiple morphological abnormalities of the flagella (MMAF). Distinct projections encircling the central microtubules of the spermatozoal axoneme play pivotal roles in flagellar bending and spermatozoal movement. Mammalian sperm-associated antigen 17 (SPAG17) encodes a conserved axonemal protein of cilia and flagella, forming part of the C1a projection of the central apparatus, with functions related to ciliary/flagellar motility, skeletal growth, and male fertility.

The construction and validation of the novel nomograms for the risk prediction of prenatal depression: a cross-sectional study.

Background: Nomograms are superior to traditional multivariate regression models in the competence of quantifying an individual's personalized risk of having a given condition. To date, no literature has been found to report a quantified risk prediction model for prenatal depression. Therefore, this study was conducted to investigate the prevalence and associated factors of prenatal depression.

Pharmacotherapeutic potential of bilobetin to combat chromium induced hepatotoxicity via regulating TLR-4, Nrf-2/Keap-1, JAK1/STAT3 and NF-κB pathway: A pharmacokinetic and molecular dynamic approach.

Background: Chromium (Cr) is one of the top-notch noxious heavy metals that is documented to exert deleterious effects on various body organs including the liver. Bilobetin (BLB) is a natural flavonoid which exhibits a wide range of medicinal properties.

Aim: This trial was executed to investigate the pharmacotherapeutic potential of BLB to avert Cr instigated hepatotoxicity via modulating TLR4, JAK1/STAT3, Nrf-2/Keap-1 and NF-κB pathway.

SKIN ANTISEPSIS PRACTICES FOR CENTRAL NEURAXIAL BLOCKADE.

Background: Skin antisepsis is essential before the central neuraxial blockade. Various antiseptic solutions are in clinical use, like povidone-iodine, alcohol, or chlorhexidine. This study was conducted to assess current practices for skin antisepsis before central neuraxial blockade and observe the compliance of anaesthesiologists with international standards in Teaching Hospitals in Karachi, Pakistan.

Giant paediatric thymoma and its tailored anaesthetic management.

A toddler presented with significant weight loss and lethargy. His CT scan chest revealed a sizeable anterior mediastinal mass of 14.5×12.

Systematic review and meta-analysis of interventions to improve outcomes for parents or carers of children with anxiety and/or depression.

Question: Depression and anxiety are common among children and young people and can impact on the well-being of their parents/carers. Dominant intervention approaches include parent training; however, this approach does not directly address parents' well-being. Our objective was to examine the effect of interventions, with at least a component to directly address the parents' own well-being, on parents' well-being outcomes, including stress, depression and anxiety.

An overview of critical applications of resistive random access memory.

The rapid advancement of new technologies has resulted in a surge of data, while conventional computers are nearing their computational limits. The prevalent von Neumann architecture, where processing and storage units operate independently, faces challenges such as data migration through buses, leading to decreased computing speed and increased energy loss. Ongoing research aims to enhance computing capabilities through the development of innovative chips and the adoption of new system architectures.

Evaluating the Correlation Between Prosthodontic Interventions and Chest Infections: A Comprehensive Research Analysis.

Background: There is growing interest in the relationship between prosthodontic therapies and outcomes related to systemic health, particularly respiratory infections. Respiratory infections are a leading cause of global morbidity and mortality, particularly among vulnerable populations such as immunocompromised individuals. The World Health Organization reports that lower respiratory infections are among the top causes of death worldwide, underscoring the importance of understanding their potential link to prosthodontic procedures.

Hantavirus-induced cardiac tamponade: A diagnostic dilemma.

Herein we describe a case of a 60-year-old white male from New York City who was admitted to hospital due to worsening dyspnea. He presented with an acute onset of fever, night sweats, and progressively worsening nonproductive cough and orthopnea over the preceding week. Electrocardiogram findings revealed atrial fibrillation.

Modified median quartile double ranked set sampling for estimation of population mean.

Environmental monitoring and assessment aim to gather data economically, without bias, using efficient and cost-effective sampling methods. One such traditional method is Ranked Set Sampling (RSS), often employed to achieve observational economy. This article introduces an innovative two-stage sampling approach for ranked set sampling (RSS) to get a more precise estimate of the population mean.

Impact of an intervention for perinatal anxiety on breastfeeding: findings from the Happy Mother-Healthy Baby randomized controlled trial in Pakistan.

Background: The study examined the effects of Happy Mother-Healthy Baby (HMHB), a cognitive-behavioural therapy (CBT) intervention on breastfeeding outcomes for Pakistani women with prenatal anxiety.

Methods: Breastfeeding practices were evaluated in a randomized controlled trial between 2019 and 2022 in a public hospital in Pakistan. The intervention group was randomized to receive six HMHB sessions targeted towards prenatal anxiety (with breastfeeding discussed in the final session), while both groups also received enhanced usual care.

Magnetic Resonance Imaging Signs of Idiopathic Intracranial Hypertension.

Importance: The magnetic resonance imaging (MRI) criteria currently used to diagnose idiopathic intracranial hypertension (IIH) are based on expert opinion and have limited accuracy. Additional neuroimaging signs have been proposed and used with contradictory results; thus, prospective evidence is needed to improve diagnostic accuracy.

Objective: To provide evidence-based, accurate MRI signs for IIH diagnosis.

Modified 5-Item Frailty Index: A Useful Tool for Assessing the Impact of Frailty on Postoperative Morbidity and Mortality Following Surgical Fixation of Thoracolumbar Fractures.

Objectives: The modified 5-item frailty index (mFI-5) is a comorbidity-based risk stratification tool to predict adverse events following various neurologic surgeries. This study aims to quantify the association between increased mFI-5 and postoperative complications and mortality following surgical fixation of traumatic thoracolumbar fractures.

Methods: The 2011-2021 American College of Surgeons - National Surgical Quality Improvement Program (ACS-NSQIP) dataset was used to identify patients undergoing fusion surgeries for thoracolumbar spine fractures.

Exploring dental professionals' outlook on the future of dental care amidst the integration of artificial intelligence in dentistry: a pilot study in Pakistan.

Objective: The purpose of this study is to explore the perspectives, familiarity, and readiness of dental faculty members regarding the integration and application of artificial intelligence (AI) in dentistry, with a focus on the possible effects on dental education and clinical practice.

Methodology: In a mix-method cross-sectional quantitative and quantitative study conducted between June 1st and August 30th, 2023, the perspectives of faculty members from a public sector dental college in Pakistan regarding the function of AI were explored. This study used qualitative as well as quantitative techniques to analyse faculty's viewpoints on the subject.

Mesoporous CoO@CdS nanorods as anode for high-performance lithium ion batteries with improved lithium storage capacity and cycle life.

Transition metal oxides based anodes are facing crucial problems of capacity fading at long cycles and high rates due to electrode degradations. In this prospective, an effective strategy is employed to develop advanced electrode materials for lithium-ion batteries (LIBs). In the present work, a mesoporous CoO@CdS hybrid sructure is developed and investigated as anode for LiBs.

Quantized Magnetic Domain Wall Synapse for Efficient Deep Neural Networks.

The quantization of synaptic weights using emerging nonvolatile memory (NVM) devices has emerged as a promising solution to implement computationally efficient neural networks on resource constrained hardware. However, the practical implementation of such synaptic weights is hampered by the imperfect memory characteristics, specifically the availability of limited number of quantized states and the presence of large intrinsic device variation and stochasticity involved in writing the synaptic states. This article presents on-chip training and inference of a neural network using quantized magnetic domain wall (DW)-based synaptic array and CMOS peripheral circuits.

NiCoO@SnSnanosheets on carbon cloth as efficient bi-functional material for high performance supercapacitor and sensor applications.

Bi-functional materials provide an opportunity for the development of high-performance devices. Up till now, bi-functional performance of NiCoO@SnSnanosheets is rarely investigated. In this work, NiCoO@SnSnanosheets were synthesized on carbon cloth by utilizing a simple hydrothermal technique.

A Case of acute Myocardial Infarction in a Patient with Essential Thrombocythaemia Treated with Anagrelide.

Unlabelled: Anagrelide is a medication primarily used to manage thrombocytosis, an abnormal increase in platelet levels in the blood. It is often prescribed for patients with myeloproliferative disorders, such as essential thrombocythaemia (ET). Given the heightened susceptibility to thromboembolism associated with this condition, the primary emphasis in treatment revolves around reducing the risk of thrombotic events through the administration of cytotoxic agents.

In vitro-in silico pharmacology and chemistry of Stercularin, isolated from Sterculia diversifolia.

Stercularin is a coumarin, isolated from the ethyl acetate fraction of stem bark and leaves of S. diversifolia. Pharmacologically it is active against cancer, diabetes, and inflammation etc.