Publications by authors named "Nisa Maruthur"

Article Synopsis
  • Adults with type 2 diabetes face challenges in healthy eating due to social factors and often experience poor health outcomes.
  • The study involved a pilot trial where one group received medically tailored meals and nutrition support, while the control group continued with usual care to evaluate changes in diabetes management.
  • Both groups saw similar improvements in blood sugar levels, but the intervention group significantly reduced food insecurity, indicating the potential benefits of tailored meal support for vulnerable populations.
View Article and Find Full Text PDF

Introduction: The authors evaluated whether an electronic health record clinical decision support system improves diabetes screening across a health system.

Methods: Study population included adults without diabetes attending a visit at 27 primary care clinics. Outcomes included the monthly screening laboratory order rate and completion rate among eligible patient visits.

View Article and Find Full Text PDF
Article Synopsis
  • Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
  • Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
  • The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
View Article and Find Full Text PDF

Introduction: Youth with diabetes should transition from paediatric to adult diabetes services in a deliberate, organized and cooperative way. We sought to identify healthcare professionals' (HCPs) experiences and perceptions around transition readiness planning, policies and procedures, and the actual transfer to adult services.

Methods: Data were collected via an online global survey (seven language options), broadly advertised by the International Society for Pediatric and Adolescent Diabetes (ISPAD), European Association for the Study of Diabetes (EASD), team members and partners, via newsletters, websites, e-mails and social media.

View Article and Find Full Text PDF

Background: Prediabetes, a high-risk state for developing diabetes, affects more than 1 in 3 adults nationally. However, <5% of people with prediabetes are receiving any treatment for prediabetes. Prior intervention studies for increasing prediabetes treatment uptake have largely focused on individual barriers with few multi-level interventions that address clinician- and system-level barriers.

View Article and Find Full Text PDF

Despite extensive evidence related to the prevention and management of type 2 diabetes (T2D) and its complications, most people at risk for and people who have diabetes do not receive recommended guideline-based care. Clinical implementation of proven care strategies is of the utmost importance because without this, even the most impressive research findings will remain of purely academic interest. In this review, we discuss the promise and challenges of implementing effective approaches to diabetes prevention and care in the real-world setting.

View Article and Find Full Text PDF
Article Synopsis
  • Many adults in the US have pre-diabetes, but not enough people are getting help to prevent type 2 diabetes.
  • Researchers followed a three-step plan to figure out how to better help these people by looking at current practices, talking to doctors and patients, and creating a support plan.
  • They found that not many patients were receiving help and that both patients and doctors often didn't know enough about pre-diabetes, leading them to create a new program called the START Diabetes Prevention Clinical Pathway to improve care.
View Article and Find Full Text PDF

Background: Prediabetes is a highly prevalent condition that heralds an increased risk of progression to type 2 diabetes, along with associated microvascular and macrovascular complications. The Diabetes Prevention Program (DPP) is an established effective intervention for diabetes prevention. However, participation in this 12-month lifestyle change program has historically been low.

View Article and Find Full Text PDF

Background: Time-restricted eating (TRE) lowers body weight in many studies. Whether TRE induces weight loss independent of reductions in calorie intake, as seen in rodent studies, is unknown.

Objective: To determine the effect of TRE versus a usual eating pattern (UEP) on body weight in the setting of stable caloric intake.

View Article and Find Full Text PDF

Aims/hypothesis: We examined the association of attainment of diabetes remission in the context of a 12 year intensive lifestyle intervention with subsequent incidence of chronic kidney disease (CKD) and CVD.

Methods: The Look AHEAD study was a multi-centre RCT comparing the effect of a 12 year intensive lifestyle intervention with that of diabetes support and education on CVD and other long-term health conditions. We compared the incidence of CVD and CKD among 4402 and 4132 participants, respectively, based on achievement and duration of diabetes remission.

View Article and Find Full Text PDF

Background: Hypoglycaemia from diabetes treatment causes morbidity and lower quality of life, and prevention should be routinely addressed in clinical visits.

Methods: This mixed methods study evaluated how primary care providers (PCPs) assess for and prevent hypoglycaemia by analyzing audio-recorded visits from five Veterans Affairs medical centres in the US. Two investigators independently coded visit dialogue to classify discussions of hypoglycaemia history, anticipatory guidance, and adjustments to hypoglycaemia-causing medications according to diabetes guidelines.

View Article and Find Full Text PDF

Background: Guidelines recommend deintensifying hypoglycemia-causing medications for older adults with diabetes whose hemoglobin A1c is below their individualized target, but this rarely occurs in practice.

Objective: To understand physicians' decision-making around deintensifying diabetes treatment.

Design: National physician survey.

View Article and Find Full Text PDF
Article Synopsis
  • A quality improvement project was conducted in a suburban primary care clinic to increase diabetes screening rates, which were initially only 51%, aligning with national averages.
  • The project involved a two-phase intervention that included generating EHR reports and using a clinical decision support tool to streamline the screening process.
  • As a result, screening rates increased to 65%, with high laboratory test completion rates, and most physicians reported the intervention as beneficial and effective.
View Article and Find Full Text PDF

Background: Since the COVID-19 pandemic, telehealth has been widely adopted in outpatient settings in the United States. Although telehealth visits are publicly accepted in different settings, little is known about the situation after the wide adoption of telehealth from the perspectives of adults with type 2 diabetes mellitus (T2D) and their providers.

Objective: This study aims to identify barriers and facilitators of maintaining continuity of care using telehealth for patients with T2D in a diabetes specialty clinic.

View Article and Find Full Text PDF

Objective: The Diabetes Prevention Program (DPP) is a widely implemented 12-month behavioural weight loss programme for individuals with prediabetes. The DPP covers nutrition but does not explicitly incorporate cooking skills education. The objective of the current study is to describe food and cooking skills (FACS) and strategies of recent DPP participants.

View Article and Find Full Text PDF

Introduction: Systematic reviews of interventions for diabetes prevention have focused on lifestyle interventions, including the Diabetes Prevention Program (DPP) and translations of the DPP. However, nationally, few people with prediabetes have joined or completed a DPP, with one cited barrier being committing to a yearlong program. This study was a systematic review to evaluate the effectiveness of lower-intensity lifestyle interventions for prediabetes on weight change, glycemia, and health behaviors.

View Article and Find Full Text PDF

The efficacy of time-restricted eating for weight loss has not been established, as prior studies were limited by a lack of controlled isocaloric designs. This study describes the design and implementation of interventions in a controlled eating study evaluating time-restricted eating. We designed a randomized, controlled, parallel-arm eating study comparing time-restricted eating (TRE) to a usual eating pattern (UEP) for the primary outcome of weight change.

View Article and Find Full Text PDF

Objective: To characterize food agency (one's capacity to procure and prepare food in particular contexts) among Diabetes Prevention Program (DPP) participants and gather perspectives about experiences with DPP.

Design: Photograph-elicitation in-depth interviews and survey measures.

Setting: Baltimore, Maryland (June-August 2021).

View Article and Find Full Text PDF

Objective: To determine physicians' approach to deintensifying (reducing/stopping) or switching hypoglycemia-causing medications for older adults with type 2 diabetes.

Research Design And Methods: In this national survey, U.S.

View Article and Find Full Text PDF

As the worldwide prevalence of overweight and obesity continues to rise, so too does the urgency to fully understand mediating mechanisms, to discover new targets for safe and effective therapeutic intervention, and to identify biomarkers to track obesity and the success of weight loss interventions. In 2016, the American Heart Association sought applications for a Strategically Focused Research Network (SFRN) on Obesity. In 2017, 4 centers were named, including Johns Hopkins University School of Medicine, New York University Grossman School of Medicine, University of Alabama at Birmingham, and Vanderbilt University Medical Center.

View Article and Find Full Text PDF

The coronavirus disease 2019 (COVID-19) pandemic has rapidly transformed health care delivery into telehealth visits. Attending regular medical appointments are critical to prevent or delay diabetes-related complications. Although telehealth visits have addressed some barriers to in-person visits, appointment no-shows are still noted in the telehealth setting.

View Article and Find Full Text PDF

Background: While many older adults with type 2 diabetes have tight glycemic control beyond guideline-recommended targets, deintensifying (stopping or dose-reducing) diabetes medications rarely occurs.

Objective: To explore the perspectives of older adults with type 2 diabetes around deintensifying diabetes medications.

Design: This qualitative study used individual semi-structured interviews, which included three clinical scenarios where deintensification may be indicated.

View Article and Find Full Text PDF