Publications by authors named "Nirupama Darshan Verma"
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Synopsis of recent research by authors named "Nirupama Darshan Verma"
- Nirupama Darshan Verma's research primarily focuses on the role of interleukin-12 (IL-12p70) in stimulating the production of Th1-like CD4(+)CD25(+) T regulatory cells, which are crucial for promoting transplant tolerance and preventing allograft rejection in various models.
- The findings indicate that the generated antigen-specific Treg cells can effectively inhibit rejection of cardiac allografts in rat models, by specifically targeting alloreactive CD4(+) T cells, which could have significant implications for improving transplant outcomes.
- Verma's work highlights the potential of manipulating Treg cells and their interaction with cytokines like IL-2 and IL-12p70 as a therapeutic strategy to enhance transplant acceptance and reduce the need for long-term immunosuppression.
