Publications by authors named "Nirmalee Fernando"
Article Synopsis
- Usher syndrome (USH) is a genetic disorder that causes hearing loss, vision loss due to retinitis pigmentosa, and balance issues, classified into three types without early detection biomarkers.
- The study investigated the differences in microRNA (miRNA) expression in cell lines from USH patients versus healthy controls, using Epstein-Barr virus to transform lymphocytes for analysis.
- Findings showed 92 miRNAs were differentially expressed in USH, with specific patterns tied to each type, and three crucial miRNAs associated with sensory development were notably downregulated, offering potential insights for identifying USH.
Circulating miRNA has recently emerged as important biomolecules with potential clinical values as diagnostic markers for several diseases. However, to be used as such, it is critical to accurately quantify miRNAs in the clinic. Yet, preanalytical factors that can affect an error-free quantification of these miRNAs have not been explored.
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