Effectiveness of pharmacological treatments for severe agitation in real-world emergency settings: protocol of individual-participant-data network meta-analysis.

Background: Severe psychomotor agitation and aggression often require immediate pharmacological intervention, but clear evidence-based recommendations for choosing among the multiple options are lacking. To address this gap, we plan a systematic review and individual-participant-data network meta-analysis to investigate their comparative effectiveness in real-world emergency settings with increased precision.

Methods: We will include randomized controlled trials investigating intramuscular or intravenous pharmacological interventions, as monotherapy or in combination, in adults with severe psychomotor agitation irrespective of the underlying diagnosis and requiring rapid tranquilization in general or psychiatric emergency settings.

Assessment of Stress, Resilience, and Coping Style among Medical Students and Effectiveness of Intervention Programs on Stress Level in South India: A Non-randomized Control Trial.

Background: Uncontrolled stress can be made at ease through resilient emotions and higher coping skills. The study aimed at assessing the level of stress, resilience, and coping among medical students and to study the effect of stress intervention programs on the stress level.

Materials And Methods: This was a nonrandomized control trial among 526 medical students which used medical student stress questionnaire, and perceive stress scale (PSS), resilience assessment using a 25-item resilience scale, and coping using a modified Pareekh scale.

Haloperidol plus promethazine for psychosis-induced aggression.

Background: Health services often manage agitated or violent people, and for emergency psychiatric services such behaviour is particularly prevalent (10%). The drugs used in this situation should ensure that the person swiftly and safely regains composure.

Objectives: To examine whether haloperidol plus promethazine is an effective treatment for psychosis induced agitation/aggression.

Effects of stimulus intensity on the efficacy and safety of twice-weekly, bilateral electroconvulsive therapy (ECT) combined with antipsychotics in acute mania: a randomised controlled trial.

Objectives: To examine differences in speed of improvement and remission in people with mania undergoing bilateral, brief-pulse, twice-weekly electroconvulsive therapy (ECT) at stimulus intensities administered just above and 2.5 times their individually titrated seizure threshold.

Methods: Consecutive, eligible subjects with mania, prescribed ECT, were randomised to receive treatments at stimulus doses either just above or 2.

Rapid tranquillisation in psychiatric emergency settings in India: pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine.

Objective: To compare the effect of intramuscular olanzapine with intramuscular haloperidol plus promethazine on rapid tranquillisation of agitated or violent people with mental illness.

Design: Pragmatic, allocation concealed, randomised controlled trial.

Setting: Emergency services of a general hospital psychiatry department in Vellore, south India.