Publications by authors named "Nirmal Muthukumarasamy"
Systematic review and meta-analysis of the impact of infectious diseases consultation on outcomes of bacteremia in children.
Antimicrob Steward Healthc Epidemiol
November 2024
Article Synopsis
- Infectious Diseases consultation (IDC) is effective in reducing both mortality and recurrence rates in adults with bacteremia (SAB)
- A systematic review and meta-analysis show IDC also significantly lowers mortality for children with SAB
- The effect of IDC on recurrence rates in pediatric cases showed moderate variability among the studies analyzed
Article Synopsis
- Brodie's abscess is a type of slow-developing bone infection, often appearing months to years after an injury.
- Staphylococcus aureus is the most common bacteria responsible for this condition, while Gram-negative bacteria are rare.
- Treatment typically involves a mix of surgery to remove infected tissue and targeted antibiotics, as demonstrated in a case where a patient successfully recovered from a Brodie's abscess in the heel.
Article Synopsis
- Mucormycosis, a rare but serious infection, saw an increase in incidence rates from 1.9 to 3.3 per 100,000 hospitalizations in the US from 2003 to 2022, peaking at 5.9 during the COVID-19 Delta wave in 2021.
- A study involving 201 patients showed that commonly associated conditions included diabetes (59.1%) and leukemia (28.9%), and the types of mucormycosis identified most frequently were rhino-orbital and pulmonary.
- Although 90-day and 1-year mortality rates were high at 35.3% and 49.8%,
The brown recluse spider () is endemic to the southcentral Midwest and the Southern United States. A bite from a brown recluse spider may result in symptoms that range from local skin necrosis to systemic complications such as acute haemolytic anaemia, disseminated intravascular coagulopathy, rhabdomyolysis and death. Although rare, systemic loxoscelism is a clinical diagnosis of exclusion that should be considered in a patient with acute autoimmune haemolytic anaemia.
View Article and Find Full Text PDFis amongst the most common chronic bacterial infection in humans. Pediatric patients appear to differ from their adult counterparts in terms of the prevalence, the complication rate, and the rate of antibiotic resistance. In this report, we present an 18-year-old man without any past medical history who was evaluated after an episode of syncope.
View Article and Find Full Text PDFspecies are Gram-negative bacilli and fastidious bacteria that can cause a number of clinical syndromes, including blood culture-negative infective endocarditis (IE). The two most commonly isolated species in humans are the agent of trench fever, and mostly known for causing cat scratch disease (Edouard et al., 2015 [1]; Edouard and Raoult, 2010 [2]).
View Article and Find Full Text PDFWe report one of the unusual presentations of disseminated gonococcal infection. This case report describes a 24-year-old woman who presented with disseminated gonococcal infection manifesting as meningitis. Cerebrospinal fluid (CSF) and throat swab PCR were positive for Blood and CSF cultures were negative for bacterial growth.
View Article and Find Full Text PDFA 54-year-old man who was previously found to be COVID-19 positive received two doses of mRNA-1273 (Moderna) vaccine 4 weeks apart, as recommended by the manufacturer. He was brought to the emergency department 1 day after second dose of the vaccine with altered mental status, headache and high fever. The patient was hospitalised for 2 days and managed with supportive care.
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