Publications by authors named "Nirjhar Banerjee"
The ribosome, a ribonucleoprotein complex, performs the function of protein translation. While ribosomal RNA catalyzes polypeptide formation, several proteins assist the ribosome throughout the translation process. Studying the biochemical and kinetic properties of these proteins interacting with the ribosome is vital for elucidating their roles.
View Article and Find Full Text PDFArticle Synopsis
- - Malaria is a neglected infectious disease, and drug development for its treatment faces significant challenges, including long timelines for FDA approval and the rapid emergence of drug resistance among malaria-causing organisms.
- - Drug discovery involves various methods such as natural sourcing, computational docking, and repurposing existing drugs, while also considering the interactions between the Plasmodium species and its human host to enhance efficacy.
- - Utilizing machine learning and systems-based approaches can improve the drug development process by analyzing genomic and proteomic data to better understand drug interactions and side effects on the host.
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ failure, and eventually death. Cytokine storm due to excess cytokine production has been associated with fatality in severe infections. However, the specific molecular signatures associated with the elevated immune response are yet to be elucidated.
View Article and Find Full Text PDFUnlabelled: An Internet computing server has been developed to identify all the occurrences of the internal sequence repeats in a protein and DNA sequences. Further, an option is provided for the users to check the occurrence(s) of the resultant sequence repeats in the other sequence and structure (Protein Data Bank) databases. The databases deployed in the proposed computing engine are up-to-date and thus the users will get the latest information available in the respective databases.
View Article and Find Full Text PDFDistant repeats in protein sequence play an important role in various aspects of protein analysis. A keen analysis of the distant repeats would enable to establish a firm relation of the repeats with respect to their function and three-dimensional structure during the evolutionary process. Further, it enlightens the diversity of duplication during the evolution.
View Article and Find Full Text PDF