Publications by authors named "Nirit Egoz"
Article Synopsis
- Crosstalk between signaling pathways is essential for creating diverse transcriptional networks, with a focus on the antagonism between the EGFR and Notch pathways, though the mechanisms remain unclear.
- Research indicates that the global corepressor Groucho (Gro) interacts with various pathways, including Notch, Wnt, and TGF-beta, and there are genetic links between Gro and the EGFR pathway.
- The study reveals that phosphorylation of Gro from MAPK activation reduces its ability to repress transcription, highlighting Gro as a key point of intersection where EGFR signaling can negatively influence Notch and potentially other pathways reliant on Gro.
