Radioactive contamination transported to Western Europe with Saharan dust.

The Reggane region, where the first French atmospheric nuclear tests were conducted in the 1960s in Southern Algeria, is located in one of the most active dust source regions responsible for recurrent massive Saharan dust events reaching Western Europe and affecting air quality. After a major outbreak in March 2022, a citizen participative science campaign was launched to study the radioactivity born by the dust. One hundred ten deposit samples were collected from six countries in Western Europe with 53 demonstrated as scientifically representative.

Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis.

Calcium accumulation in atherosclerotic plaques predicts cardiovascular mortality, but the mechanisms responsible for plaque calcification and how calcification impacts plaque stability remain debated. Tissue-nonspecific alkaline phosphatase (TNAP) recently emerged as a promising therapeutic target to block cardiovascular calcification. In this study, we sought to investigate the effect of the recently developed TNAP inhibitor SBI-425 on atherosclerosis plaque calcification and progression.