Publications by authors named "Niravkumar Brahmbhatt"
Immune checkpoint inhibitors (CPIs) can cause immune-related organ dysfunctions, including nephritis, pneumonitis, thyroiditis, hepatitis, colitis and more rarely hematological toxicities like immune-related autoimmune hemolytic anemia (irAIHA). Very few cases of irAIHA associated with immunotherapy have been reported, and treatment protocols remain unclear. This is partly because not all irAIHA cases are Coomb's test positive.
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- Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe immune disorder that is hard to diagnose due to its varied causes and symptoms, often requiring intense medical care.
- HLH can either be genetic (HLH syndrome) or acquired (HLH disease), triggered by instances like infections, autoimmune diseases, or cancers; this case study presents the first known instance of HLH caused by tularemia in an older female patient.
- The patient was initially treated for suspected malignancy but switched to antimicrobial therapy after testing positive for tularemia, leading to a lengthy recovery period but ultimately highlighting the need for quick identification of triggering infections for more effective HLH treatment.