Publications by authors named "Niraja M Dighe"
Article Synopsis
- Major hemoglobinopathies, like thalassemia, can put a significant strain on healthcare systems, prompting the exploration of advanced treatment methods like intrauterine hemopoietic cell transplantation (IUHCT) and gene transfer (IUGT) to improve outcomes over traditional postnatal therapies.
- Research using thalassemic HbbTh3/+ mice showed that IUHCT with co-isogenic cells and high-dose bone marrow cells could create different levels of chimerism, resulting in better health indicators and smaller spleens compared to untreated mice.
- Although IUGT with a lentiviral vector improved some hematological measures, further optimization of doses is needed to enhance efficacy, particularly when combining IUHCT with post
