Publications by authors named "Nir Lipsman"
Introduction: Post-traumaticstress disorder (PTSD) can have debilitating effects on quality of life, andconventional treatments show mixed results. Neuromodulation is emerging as apromising approach for treating PTSD. This review examines currentneuromodulatory treatments for PTSD, and highlights methodologies, clinicaloutcomes, and gaps in the literature to help guide future research.
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Article Synopsis
- Traumatic brain injury (TBI) can lead to long-term deficits in attention and memory, and deep brain stimulation (DBS) is being explored as a potential therapy for improving these cognitive impairments.* -
- The study tested whether early DBS after TBI in male rats can prevent memory decline and promote neuroprotection by evaluating behavioral tests and measuring brain cell health and neurotrophic factors.* -
- Results showed that while DBS improved performance in some maze tests and increased levels of BDNF and hippocampal cell counts, it did not significantly enhance memory in other tests or reduce inflammatory cytokine levels in the brain.*
Article Synopsis
Background: Repetitive transcranial magnetic stimulation (rTMS) is frequently used as an adjunctive treatment with antidepressants for depression. We aimed to evaluate the clinical efficacy and safety of antidepressant classes when administered concurrently with rTMS for the management of major depressive disorder (MDD).
Methods: In this systematic review and meta-analysis, MEDLINE, Embase, PsycINFO, and the Cochrane Library were searched from inception to April 12th 2024 for terms relating to medication, depression, and rTMS and appraised by 2 independent screeners.
Article Synopsis
- The study investigates how MT1-MMP, a protease involved in cancer cell movement, is recruited to invadopodia in metastatic breast cancer cells, focusing on its interaction with a protein called plectin.
- Through techniques like mass spectrometry and siRNA, researchers found that plectin is crucial for forming invadopodia and facilitating the enzyme's delivery, significantly influencing cancer cell invasiveness.
- Targeting the MT1-MMP and plectin interaction might pave the way for new therapies aimed at reducing cancer metastasis.
Article Synopsis
- Major depressive disorder (MDD) is a serious illness that affects many people and can make life really tough, and some people don't feel better with regular treatments.
- A new study is testing a substance called psilocybin, which has shown promise in helping some people with depression quickly.
- The research will look at how psilocybin affects the brain and mood over time compared to a placebo (fake treatment) in 50 participants suffering from MDD.
Article Synopsis
- * Human safety trials have shown a promising safety profile after extensive pre-clinical studies, leading to ongoing clinical trials for conditions like Alzheimer's and Parkinson's and brain tumors.
- * Future efforts aim to enhance ultrasound delivery technology, investigate new delivery methods like nanodroplets, and broaden applications to other neurological diseases.*
Background: Patient expectations, including both positive (placebo) and negative (nocebo) effects, influence treatment outcomes, yet their impact on acute repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression (TRD) is unclear.
Methods: In this single-center retrospective chart review, 208 TRD patients completed the Stanford Expectation of Treatment Scale (SETS) before starting open-label rTMS treatment. Patients were offered two excitatory rTMS protocols (deep TMS or intermittent theta-burst stimulation), which stimulated the left dorsolateral prefrontal cortex.
Deep brain stimulation has revolutionized the treatment of movement disorders and is gaining momentum in the treatment of several other neuropsychiatric disorders. In almost all applications of this therapy, the insertion of electrodes into the target has been shown to induce some degree of clinical improvement prior to stimulation onset. Disregarding this phenomenon, commonly referred to as 'insertional effect', can lead to biased results in clinical trials, as patients receiving sham stimulation may still experience some degree of symptom amelioration.
View Article and Find Full Text PDFPurpose: We present the final analyses of tumor dynamics and their prognostic significance during a 6-week course of concurrent chemoradiotherapy for glioblastoma in the Glioblastoma Longitudinal Imaging Observational study.
Methods And Materials: This is a prospective serial magnetic resonance imaging study in 129 patients with glioblastoma who had magnetic resonance imaging obtained at radiation therapy (RT) planning (F0), fraction 10 (F10), fraction 20 (F20), and 1-month post-RT. Tumor dynamics assessed included gross tumor volume relative to F0 (V) and tumor migration distance (d).
Deep brain stimulation (DBS) is an emerging therapy for treatment-resistant depression (TRD). Although adverse effects have been reported in early-phase and a few randomized clinical trials, little is known about its overall safety profile, which has been assumed to be similar to that of DBS for movement disorders. The objective of this study was to pool existing safety data on DBS for TRD.
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- * A study analyzed the effectiveness of high frequency repetitive transcranial magnetic stimulation (rTMS) on patients with MDD, comparing those with a seasonal pattern to those without.
- * Results indicated no significant difference in treatment outcomes between patients with and without a seasonal pattern, suggesting that rTMS is effective for both groups in improving depressive symptoms.
Dose-Escalated Radiation Therapy Is Associated With Improved Outcomes for High-Grade Meningioma.
Int J Radiat Oncol Biol Phys
March 2024
Purpose: The optimal modern radiation therapy (RT) approach after surgery for atypical and malignant meningioma is unclear. We present results of dose escalation in a single-institution cohort spanning 2000 to 2021.
Methods And Materials: Consecutive patients with histopathologic grade 2 or 3 meningioma treated with RT were reviewed.
Purpose: To investigate the changes in apparent diffusion coefficient (ADC) within incrementally-increased margins beyond the gross tumor volume (GTV) on post-operative radiation planning MRI and their prognostic utility in glioblastoma.
Methods: Radiation planning MRIs of adult patients with newly diagnosed glioblastoma from 2017 to 2020 were assessed. The ADC values were normalized to contralateral normal white matter (nADC).