Publications by authors named "Niqin Xiao"
Osteoarthritis (OA), a ubiquitous degenerative joint disorder, is marked by pain and disability, profoundly impacting patients' quality of life. As the population ages, the global prevalence of OA is escalating. Omics technologies have become instrumental in investigating complex diseases like OA, offering comprehensive insights into its pathogenesis and progression by uncovering disease-specific alterations across genomics, transcriptomics, proteomics, and metabolomics levels.
View Article and Find Full Text PDFOsteoarthritis (OA) is the most common chronic degenerative joint disease, characterized by cartilage damage, synovial inflammation, subchondral bone sclerosis, marginal bone loss, and osteophyte development. Clinical manifestations include inflammatory joint pain, swelling, osteophytes, and limitation of motion. The pathogenesis of osteoarthritis has not yet been fully uncovered.
View Article and Find Full Text PDFCorrigendum: Study on the effects of intestinal flora on gouty arthritis.
Front Cell Infect Microbiol
September 2024
Article Synopsis
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Study on the effects of intestinal flora on gouty arthritis.
Front Cell Infect Microbiol
August 2024
Article Synopsis
- Gouty arthritis (GA) is mainly a joint disease linked to metabolic and immune dysfunctions, with dysbiosis (imbalance) of gut bacteria recognized as a key contributing factor.
- Changes in gut flora may trigger metabolic disorders that lead to GA, particularly in individuals with high uric acid levels, but the specific mechanisms remain unclear.
- Therapies for GA can influence gut bacteria, indicating that managing gut flora could provide new ways to prevent and treat GA, with potential insights from traditional Chinese medicine for lowering uric acid and alleviating symptoms.
Gout is a chronic metabolic and immune disease, and its specific pathogenesis is still unclear. When the serum uric acid exceeds its saturation in the blood or tissue fluid, it is converted to monosodium urate crystals, which lead to acute arthritis of varying degrees, urinary stones, or irreversible peripheral joint damage, and in severe cases, impairment of vital organ function. Gout flare is a clinically significant state of acute inflammation in gout.
View Article and Find Full Text PDFArticle Synopsis
- Gouty nephropathy (GN) is a metabolic disease characterized by high blood uric acid levels, leading to symptoms like kidney stones and chronic inflammation.
- Understanding the mechanisms behind GN is essential for creating new prevention and treatment options, as most current research relies on animal and cell models.
- The article reviews the role of inflammation, oxidative stress, and cell death in GN, outlines methods for developing models, and suggests potential models for further investigation into GN’s causes and treatment.