Publications by authors named "Niqi Shan"
Article Synopsis
- Salvianolic acid B (SalB) has potential clinical benefits, particularly for protecting the heart and brain, and this study examined its effects specifically on sepsis in mice.
- In experiments involving male C57BL/6 mice with induced sepsis, SalB was found to reduce liver and lung damage, lower inflammation, and improve blood flow in the intestines.
- The study revealed that SalB works by binding to the platelet adhesion molecule CD226, which reduces platelet clumping and improves microcirculation, suggesting SalB could be a promising treatment for sepsis.
Article Synopsis
- - The study investigates the role of CD226, a costimulatory molecule in T lymphocytes, and its involvement in the development of allergic asthma, highlighting increased expression in CD4 effector T cells in asthma patients.
- - Researchers created CD4 T cell-specific knockout mice to model allergic asthma and found that lacking CD226 reduced lung inflammation, IgE production, and airway remodeling, indicating its critical role in asthma pathology.
- - Mechanically, CD226 deletion led to increased apoptosis in CD4 T cells through a specific pathway, and blocking CD226 signaling showed potential for therapeutic benefits in asthma treatment, suggesting it could be a target for new therapies.
The objective of the study is to test whether the use of edible oil might be an early treatment strategy for reducing button battery-induced esophageal injury. A button battery was inserted into esophageal segments collected from pigs. The esophageal segments were randomly allotted to one of the following six treatments: (1) untreated (nothing injected), (2) lemon juice, (3) orange juice, (4) colza oil, (5) peanut oil, and (6) olive oil.
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