Publications by authors named "Nipa Singh"

Background And Objectives: Stroke-associated pneumonia (SAP) is the aftermath of aspiration of oropharyngeal secretions or stomach content. Mechanical ventilation and lowered immunity and consciousness facilitate the etiopathogenesis of SAP. Antibiotic prophylaxis and repeated culture and sensitivity testing dampen the drug susceptibility patterns of the pathogens.

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  • Needle stick injuries (NSIs) pose serious health risks for healthcare workers, exposing them to blood-borne infections like HIV, HBV, and HCV; this study analyzed NSI cases over four years from a hospital in India.
  • The study recorded 115 NSI cases from 2019 to 2022, with a higher incidence among younger healthcare workers, especially nurses in the initial years, while housekeeping staff were more affected in later years; most injuries occurred during morning shifts and in the inpatient department.
  • Post-exposure prophylaxis was administered to a subset of affected workers, with a negative HIV serology status for all tested, although some cases showed positive for HBV and HCV.
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Introduction: Non-fermenting gram-negative bacilli (NFGNB) infections have emerged as a serious health concern in ICUs. Multi-drug resistant (MDR) strains of NFGNB can evolve by acquiring resistance genes to at least one agent in three or more antibacterial categories. This study aimed to analyse the prevalence of NFGNB, the distribution of MDR strains, and antibiotic resistance trends of NFGNB in different ICUs of a tertiary care hospital over a period of five years.

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Unlabelled: During the onset of the pandemic, a common research question was asked by the hospital staff, and family members who were handling COVID-19-infected cadavers, "does COVID-19-positive dead body harbor SARS-CoV-2 viral RNA?" Several research findings were reported but due to the lack of proper research findings, the question remained unanswered. The present study was planned to observe the virus transmission risk from cadavers to the handlers. A pilot study was conducted on 54 cadavers who died in COVID-ICU (SARS-CoV-2-positive diagnosed by RT-PCR) during 2021-2022.

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Introduction: The rising incidence of carbapenem resistance in Enterobacterales and is a concern. Since carbapenemase production is the primary resistance mechanism, detecting and identifying the genes responsible for it is crucial to effectively monitor its spread.

Objective: This study aims to detect positivity for the modified carbapenem inactivation method (mCIM) and ethylenediaminetetraacetic acid (EDTA)-carbapenem inactivation method (eCIM) for the detection of carbapenemase-producing Enterobacterales and .

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 causes melioidosis in both humans as well as animals and is classified as a tier 1 pathogen by the US CDC. Melioidosis is a disease that occurs predominantly in subtropical and tropical regions. It is endemic to northern Australia and parts of Southeast Asia, as well as the Indian subcontinent.

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Background The coronavirus disease 2019 (COVID-19) pandemic challenged the healthcare infrastructure, with health-service providers (HSPs) offering unconditional and unprejudiced service to admitted patients. During the first wave, due to the novelty of the disease and the lack of clarity regarding its transmission in the initial phases of the evolution of the disease, the predominant fear was of contracting the disease while caring for patients. With the prevailing uncertainty in knowledge and management, this study was planned to identify the barriers to delivering optimal healthcare to COVID-19 patients.

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  • - The study focused on understanding the factors behind acute exacerbations of chronic obstructive pulmonary disease (COPD) due to infections, involving patients admitted for treatment at Kalinga Institute of Medical Sciences from October 2018 to February 2022.
  • - Researchers followed up on 197 patients, primarily elderly males and smokers from urban areas, identifying 102 pathogens responsible for exacerbations, with viral infections like rhinovirus and influenza being common, as well as various bacteria.
  • - The results highlighted that males aged 61-80 years experienced the highest rates of exacerbation, and those with coinfections faced worse clinical outcomes, including higher readmission rates.
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  • COVID-19 patients with lingering symptoms for over four weeks, termed long COVID, may develop complications due to prolonged use of medications and existing health conditions, increasing their risk of infections from multidrug-resistant bacteria.
  • A study at Kalinga Institute of Medical Sciences evaluated 84 long COVID patients to analyze the effectiveness of antibiotic treatment based on culture and sensitivity of samples collected, revealing that 78.1% had culture-positive pathogens.
  • Among the isolated pathogens, a majority (69%) were drug-resistant, predominantly Gram-negative types, leading to a concerning prognosis with five deaths reported among those infected with resistant strains.
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Introduction: Bacteria and their products play a primary etiological role in the initiation and perpetuation of pulpoperiapical pathosis. Intracanal medication is important for endodontic success as it eliminates microorganisms that persist after chemomechanical preparation.

Aim: To compare antimicrobial efficacy of calcium hydroxide powder, triple antibiotic paste, calcium hydroxide with 2% chlorhexidine solution, and triple antibiotic paste with 2% chlorhexidine solution.

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Introduction: Resistance to common antibiotics is a matter of grave concern in treating infections in hospital settings especially in Intensive Care Units (ICUs). One of the most commonly used and effective group of antibiotics, cephalosporins, exhibit resistance due to production of Extended Spectrum Beta- Lactamases (ESBLs). The prevalence of ESBL producing () has increased throughout the world and is a major cause of treatment failure in ICUs.

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