Mogamulizumab Combined with Extracorporeal Photopheresis as a Novel Therapy in Erythrodermic Cutaneous T-cell Lymphoma.

Background: Primary cutaneous T-cell lymphomas (CTCLs) are rare lymphoproliferative malignancies characterized by significant morbidity and mortality in advanced disease stages. As curative approaches apart from allogeneic stem cell transplantation are lacking, establishing new treatment options, especially combination therapies, is crucial.

Methods: This retrospective study included 11 patients with SS or MF receiving therapy with mogamulizumab in combination with ECP from four European expert centers.

Treatment satisfaction of patients with psoriasis with topical therapy in a real-world setting: unmet need for higher effectiveness.

Background: Topical medication is the mainstay for treatment of mild psoriasis. However, dissatisfaction with topicals is common and rates of non-adherence are high. Assessing patients' perspectives can help to identify unmet needs.

Patient preferences for topical psoriasis treatments: a discrete choice experiment.

Background: Topical medication continues to be the most frequently prescribed therapy for psoriasis. However, patients are often dissatisfied with their topical medication, and adherence to this type of therapy is particularly poor.

Objective: To investigate the preferences of patients with psoriasis regarding the process and outcome attributes associated with topical treatments and to assess influencing factors.

Psoriasis care during the time of COVID-19: real-world data on changes in treatments and appointments from a German university hospital.

Background: COVID-19 poses significant challenges for care of patients with chronic inflammatory skin diseases including psoriasis.

Objectives: To investigate changes in treatment and/or appointments for psoriasis patients in a German university hospital due to the pandemic.

Materials & Methods: A postal survey was conducted between May 15 and June 15, 2020.

Reducing negative affect with anodal transcranial direct current stimulation increases memory performance in young-but not in elderly-individuals.

Affect can directly influence memory storage and retrieval, which offers the opportunity to improve memory performance by changing affective responses. A promising target is the left dorsolateral prefrontal cortex (dlPFC), as it is functionally involved in both affect and memory. This study explores whether anodal transcranial direct current stimulation (tDCS) to the left dlPFC improves memory retrieval through the reduction of negative affect and if this interacts with age.