Publications by authors named "Ninoslava Lalatovic"
Article Synopsis
- Genetic factors, specifically polymorphisms in the ABCB1 gene, are linked to an increased risk of statin-associated muscle symptoms (SAMS), a major contributor to statin intolerance.
- A study found that patients with specific genotypes (TT) for the polymorphisms 1236C > T, 2677G > T/A, and 3435C > T had a significantly higher likelihood of experiencing SAMS when using atorvastatin.
- Family history of cardiovascular disease is also recognized as a risk factor for SAMS, suggesting the need for ABCB1 genotyping in clinical practice to identify patients at higher risk more effectively.
Background: Patients with dyslipidemia are usually multimorbid and require polypharmacy. Therefore, it is important to identify potential drug-drug interactions (pDDIs) in time to prevent their consequences. We aimed to identify and analyze risk factors contributing to their occurrence to guide health professionals.
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