Risk factors for Pseudomonas aeruginosa isolation in chronic obstructive pulmonary disease: a systematic review and meta-analysis.

Background: Pseudomonas aeruginosa (PA) isolation in patients with chronic obstructive pulmonary disease (COPD) has been associated with a poor prognosis. This meta-analysis aimed to determine significant risk factors for PA isolation among patients with COPD.

Methods: A systematic literature retrieval from PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) was conducted, including studies from January 2003 to September 2024.

Homogeneous Fluorine Doping toward Highly Conductive and Stable LiGePS Solid Electrolyte for All-Solid-State Lithium Batteries.

The unique structure and exceptionally high lithium ion conductivity over 10 mS cm of LiGePS have gained extensive attention in all-solid-state lithium batteries. However, its poor resistivity to moisture and chemical/electrochemical incompatibility with lithium metal severely impede its practical application. Herein, a fluorine functionalized LiGePS is synthesized by stannous fluoride doping and employed as a monolayer solid electrolyte to realize stable all-solid-state lithium batteries.

Emerging role of mesenchymal stem cell-derived exosome microRNA in radiation injury.

Purpose: Radiation injury (RI) is a common occurrence in malignant tumors patients receiving radiation therapy. While killing tumor cells, normal tissue surrounding the target area is inevitably irradiated at a certain dose, which can cause varying results of radiation injury. Currently, there are limited clinical treatments available for radiation injuries.

Early-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice.

Exercise is usually regarded to have short-term beneficial effects on immune health. Here we show that early-life regular exercise exerts long-term beneficial effects on inflammatory immunity. Swimming training for 3 months in male mice starting from 1-month-old curbs cytokine response and mitigates sepsis when exposed to lipopolysaccharide challenge, even after an 11-month interval of detraining.

Transcriptome Sequencing of Gingival Tissues from Impacted Third Molars Patients Reveals the Alterations of Gene Expression.

Objective: The removal of impacted third molars by surgery may occur with a series of complications, whereas limited information about the postoperative pathogenesis is available. The objective of this study is to identify changes in gene expression after flap surgical removal of impacted third molars and provide potential information to reduce postoperative complications.

Methods: The gingival tissues of twenty patients with flap surgical removal of impacted third molars and twenty healthy volunteers were collected for gene expression testing.

Synthesis of Graphene Oxide-Coupled CoNi Bimetallic MOF Nanocomposites for the Simultaneous Analysis of Catechol and Hydroquinone.

Herein, a three-dimensional flower-like cobalt-nickel bimetallic metal-organic framework (CoNi-MOF) coupled with two-dimensional graphene oxide (GO) nanocomposites was successfully synthesized for the selective and simultaneous electrochemical determination of catechol (CC) and hydroquinone (HQ). The three-dimensional flower-like structure of the CoNi-MOF/GO nanocomposite has a multilayer structure and a large surface area, which greatly improves its electrocatalytic activity towards CC and HQ. Differential pulse voltammetry (DPV) results showed that the peak-to-peak separation of CC (0.

Risk of Fracture and Osteoporosis in Patients With COPD and Inhaled Corticosteroids Treatment.

Background: There are disputes whether inhaled corticosteroids (ICS) increase the incidence of fracture or osteoporosis among patients with COPD. The aim of this meta-analysis was to assess the effect of ICS treatment on the risk of fracture and osteoporosis in subjects with COPD.

Methods: This study included parallel-group randomized controlled trials (RCTs) comparing ICS and control (non-ICS) therapy for subjects with COPD that reported adverse events including fractures or osteoporosis.

Crystal Engineering of TiO for Enhanced Catalytic Oxidation of 1,2-Dichloroethane on a Pt/TiO Catalyst.

Crystal engineering of metal oxide supports represents an emerging strategy to improve the catalytic performance of noble metal catalysts in catalytic oxidation of chlorinated volatile organic compounds (CVOCs). Herein, Pt catalysts on a TiO support with different crystal phases (rutile, anatase, and mixed phase (P25)) were prepared for catalytic oxidation of 1,2-dichloroethane (DCE). The Pt catalyst on P25-TiO (Pt/TiO-P) showed optimal activity, selectivity, and stability, even under high-space velocity and humidity conditions.

Repair mechanism of radiation-induced salivary gland injury by hypoxia-pretreated human urine-derived stem cell exosomes.

Objective: To explore the protective effect of human urine-derived stem cell exosomes (hUSC-Exos) on radiation-induced salivary gland (SG) injuries in Sprague Dawley rats.

Methods: Fresh adult urine was collected, and primary hUSCs were isolated and identified. The hUSCs were hypoxia-pretreated with 1% oxygen for 24 h and then transferred to a normoxic culture environment for 24 h.

Study on the Rural Revitalization and Urban-Rural Integration Efficiency in Anhui Province Based on Game Cross-Efficiency DEA Model.

By taking the 16 cities in Anhui Province for evaluation, the main influencing factors and indicator system for integrated urban-rural development in the new era were explored, to build the BCC model, cross-efficiency model, and game cross-efficiency model of DEA. The above models were applied for empirical analysis and comparative study on the rural revitalization and urban-rural integration efficiency in Anhui Province, to summarize the conclusions efficiency and give suggestions based on the above calculations.

Influence of prefoldin subunit 4 on the tolerance of Kluyveromyces marxianus to lignocellulosic biomass-derived inhibitors.

Background: Kluyveromyces marxianus is a potentially excellent host for microbial cell factories using lignocellulosic biomass, due to its thermotolerance, high growth rate, and wide substrate spectrum. However, its tolerance to inhibitors derived from lignocellulosic biomass pretreatment needs to be improved. The prefoldin complex assists the folding of cytoskeleton which relates to the stress tolerance, moreover, several subunits of prefoldin have been verified to be involved in gene expression regulation.

Infant and preschooler feeding behaviors in Chinese families: A systematic review.

A systematic review was conducted on the literature on feeding behaviors in Chinese families of children under 6 years old. Forty relevant publications were identified, of which 33 were published in Chinese, 7 in English. All studies were questionnaire-based and used a cross-sectional research design.

Astragaloside IV Alleviates the Experimental DSS-Induced Colitis by Remodeling Macrophage Polarization Through STAT Signaling.

Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation, which currently lacks safe and effective medicine. Some previous studies indicated that Astragaloside IV (AS-IV), a natural saponin extracted from the traditional Chinese medicine herb , alleviates the experimental colitis symptoms and . However, the mechanism of AS-IV on IBD remains unclear.

The modified endoscopic retrograde appendicitis therapy versus antibiotic therapy alone for acute uncomplicated appendicitis in children.

Background: Endoscopic retrograde appendicitis therapy (ERAT) is an emerging endoscopic treatment modality for acute uncomplicated appendicitis (AUA) supported by several case series. However, to date, systematic studies have not been conducted in children and the prospective comparative data are lacking. Moreover, due to a concern for future malignancy risk in children from ionizing radiation, we used contrast-enhanced ultrasound (CEUS) instead of endoscopic retrograde appendiceal radiography (ERAR).

The Effect of Zigzag Palatoplasty on the Repair of Cleft Palate and its Comparative Study With Sommerlad Palatoplasty and the Double Opposing Z Palatoplasty.

Purpose: At present, there are a variety of surgical methods for cleft palate repair, the authors first created the zigzag plasty of nasal mucosa musculature. The method is characteristic of better repair effect for anatomy and function of palatopharyngeal compared with the traditional method.

Methods: Fifty patients with cleft palate were involved in this study, and treated with 3 different operative methods, respectively: zigzag palatoplasty for the repair of nasal mucosa myometrium (n = 17), Sommerlad palatoplasty (n = 18) and the double opposing Z palatoplasty (n = 15), respectively.

[Establishment of a congenital chloride diarrhea-associated SLC26A3 c.392C>G (p.P131R) polymorphism-expressing cell model and a preliminary analysis of its mechanism of action].

Objective: To establish a congenital chloride diarrhea (CCD)-associated SLC26A3 c.392C>G (p.P131R) polymorphism-expressing cell model, and to investigate its biological function.

Metagenomic Analysis Identified Pneumonia in an Infant Suffering From Unexplained Very Severe Pneumonia.

Pneumonia poses a significant global morbidity and mortality burden on children. Etiological diagnosis and matched anti-microbial therapy are particularly important for very severe pneumonia. Although great advances have been achieved in diagnostic approaches, it remains challenging to identify pathogens in unexplained pneumonia (UP) cases.

Functional characterization of SLC26A3 c.392C>G (p.P131R) mutation in intestinal barrier function using CRISPR/CAS9-created cell models.

Background: Congenital chloride diarrhea (CCD) in a newborn is a rare autosomal recessive disorder with life-threatening complications, requiring early diagnostics and treatment to prevent severe dehydration and infant mortality. SLC26A3 rs386833481 (c.392C>G; p.

Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen.

Acetaminophen (APAP) is a commonly used analgesic responsible for more than half of acute liver failure cases. Identification of previously unknown genetic risk factors would provide mechanistic insights and novel therapeutic targets for APAP-induced liver injury. This study used a genome-wide CRISPR-Cas9 screen to evaluate genes that are protective against, or cause susceptibility to, APAP-induced liver injury.

Optimization of ultrasound-assisted extraction of indigo and indirubin from Fort. and their antioxidant capacities.

An effective method for the ultrasound-assisted extraction of indigo and indirubin from Fort. was established and their antioxidant activities were investigated. Response surface methodology based on a three-level, four-factor Box-Behnken design was used to optimize the extraction conditions.

Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity.

Acetaminophen is commonly used to reduce pain and fever. Unfortunately, overdose of acetaminophen is a leading cause of acute liver injury and failure in many developed countries. The majority of acetaminophen is safely metabolized in the liver and excreted in the urine; however, a small percentage is converted to the highly reactive -acetyl--benzoquinone imine (NAPQI).

Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.

Acetaminophen overdose is the most common cause of acute liver injury (ALI) or acute liver failure in the United States. Its pathogenetic mechanisms are incompletely understood. Additional studies are warranted to identify new genetic risk factors for more mechanistic insights and new therapeutic target discoveries.

Aspirin Inhibits IKK-β-mediated Prostate Cancer Cell Invasion by Targeting Matrix Metalloproteinase-9 and Urokinase-Type Plasminogen Activator.

Background/aims: Aspirin has been demonstrated to possess potent chemopreventive and anticancer effects on prostate cancer. However, the more detailed molecular mechanisms of aspirin to suppress prostate cancer cell invasion have not been clearly elucidated.

Methods: Transwell assays were performed to evaluate the effects of aspirin on cell invasion.

[Effects of aspirin on dendritic cells in the inflammatory microenvironment of rabbit buccal VX-2 squamous cell carcinoma].

Objective: To explore the effects of aspirin and inflammation on the maturation and function of dendritic cells (DC) on the supernatant of VX-2 squamous cell carcinoma.

Methods: The rabbit buccal VX-2 squamous cell carcinoma models with inflammation were established by tumor particle implantation, mechanical trauma, and high sugar diet. The rabbits were divided into three groups.

[Effects of anti-infection treatment on expressions of HLA-DR and CD86 in dendritic cells in rabbit buccal VX2 squamous cell carcinoma tissue with inflammation].

Objective: To investigate the effects of anti-infection treatment on the expressions of antigen-presenting-related membrane-surface molecules HLA-DR and CD86 in dendritic cells (DCs) in rabbit buccal VX2 squamous cell carcinoma tissue complicated with local inflammation.

Methods: Rabbit buccal VX2 squamous cell carcinoma with local inflammation models that were established by inflammation was induced by inoculation VX2 tumor, mechanical trauma, and drinking of milk with high sugar viscosity. The animals were divided into four groups.