Publications by authors named "Ningyu Sun"

Norfloxacin (NOR) is frequently detected in various water bodies and has the potential to promote the proliferation of NOR-resistant bacteria/genes in the environment. Efficiently removing residual NOR and NOR-resistant bacteria from contaminated water is critical to mitigating their environmental risks. This study investigated the ability of two common clay minerals, kaolinite and montmorillonite, to remove NOR and NOR-resistant bacteria from five different water environments (ultrapure water, simulated and real freshwater, and simulated and real seawater) and explored the underlying removal mechanisms.

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  • - Pharmaceutical wastewater treatment plants (PWWTPs) can harbor antibiotic-resistant bacteria (ARBs) and genes, with the study isolating a multiantibiotic-resistant Acinetobacter lwoffii (N4) from sludge, showing high resistance to various antibiotics and metals.
  • - The strain N4 displayed enhanced resistance when exposed to both antibiotics and heavy metals, suggesting a synergistic effect on its resilience against treatments.
  • - Whole-genome sequencing revealed 23 antibiotic resistance genes, along with significant virulence factors, indicating N4's potential to be pathogenic and the risks associated with multidrug-resistant bacteria in wastewater systems.
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  • Debates on human germline genome editing typically focus on genetic changes in gametes and embryos, while the heritable potential of editing somatic (non-reproductive) cells has been largely overlooked.
  • Advances like induced pluripotent stem cells and technologies for creating gametes from somatic cells raise the possibility that edits to these cells could pass on to future generations.
  • Due to the flexibility of fetal tissues, there's a risk that genome edits made for therapeutic purposes could unintentionally affect the germline, leading to calls for strict regulatory oversight to ensure safety and ethical compliance in genome editing practices.
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The phase transition of AF difluorides strongly depends on pressure, temperature, and cationic radius. Here, we have investigated the phase transition of three difluorides, including MgF, CaF, and BaF, at simultaneously high pressures and temperatures using Raman spectroscopy and X-ray diffraction in externally heated diamond anvil cells up to 55 GPa at 300-700 K. Rutile-type difluoride MgF with a small cationic radius undergoes a transition to the CaCl-type phase at 9.

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The majority of women who freeze their eggs for non-medical or social reasons, commonly referred to as elective egg freezing (EEF), do not eventually utilize their frozen eggs. This would result in an accumulated surplus of unused frozen eggs in fertility clinics worldwide, which represents a promising source of donation to infertile women undergoing IVF treatment. Rigorous and comprehensive counseling is needed, because the process of donating one's unused surplus frozen eggs involves complex decision-making.

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Many clinical studies have shown that embryos of fertilization (IVF) are often prone to developmental arrest, which leads to recurrent failure of IVF treatment. Early embryonic arrest has always been an urgent clinical problem in assisted reproduction centers. However, the molecular mechanisms underlying early embryonic development arrest remain largely unknown.

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The aim of this study was to analyze and compare the differential expression of peptides within the follicular fluid of polycystic ovary syndrome (PCOS) patients normal women by using peptidomics techniques. The underlying mechanisms involved in PCOS pathogenesis will be explored, together with screening and identification of potential functional peptides via bioinformatics analysis. A total of 12 patients who underwent fertilization and embryo transfer (IVF-ET) at the Reproductive Medicine Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from 1 September 2022 to 1 November 2022 were included in this study.

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Background: Herein, we aimed to analyse the effects of body mass index (BMI) on the treatment outcomes of in vitro fertilisation (IVF) in a cohort of women undergoing their first IVF cycle.

Methods: A total of 2311 cycles from 986 women undergoing their first IVF/intracytoplasmic sperm injection cycle with fresh/frozen embryo transfer between January 2018 and December 2021 at the Center of Reproductive Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, were considered in this retrospective cohort study. First, the included patients were classified into four groups based on their BMI: underweight (BMI < 18.

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Silicate and oxide glasses are often chemically doped with a variety of cations to tune for desirable properties in technological applications, but their performances are often limited by relatively lower mechanical and elastic properties. Finding a new route to synthesize silica-based glasses with high elastic and mechanical properties needs to be explored. Here, we report a dense SiO-glass with ultra-high elastic moduli using sound velocity measurements by Brillouin scattering up to 72 GPa at 300 K.

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The elasticity of minerals under high pressure-temperature conditions is crucial for constraining mantle composition. This perspective highlights recent advances in experimental and theoretical work in determining the elasticity of minerals to resolve the origin of low-velocity layers and the seismic anisotropy in the top lower mantle.

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Arabidopsis thaliana, one of the most important model plants, has played an essential role in every biological field including evolutionary biology. Recent population genomic studies have gradually clarified the origin and evolution of this species. Nevertheless, incongruent patterns among gene trees based on cytogenetic data have highlighted the importance of understanding the life history evolution and landscape biogeography of extant A.

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