Publications by authors named "Ningqiu Yuan"
The Toll/interleukin-1 receptor (TIR) signaling domain is distributed widely in mammalian Toll-like receptors and adaptors, plant nucleotide-binding leucine-rich repeat receptors, and specific bacterial virulence proteins. Proteins that possess TIR domain exhibit NADase activity which is distinct from the canonical signaling function of these domains. However, the effects of bacterial TIR domain proteins on host metabolic switches and the underlying mechanism of NADase activity in these proteins remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- - Brucella, an intracellular bacterium, mainly relies on replicating inside host cells, and a mutant strain lacking the alr gene showed heightened immune responses in mice.
- - Immunized mice exhibited increased spleen weight and elevated serum IgG levels, while the bacterial load in the spleen decreased, indicating a stronger immune reaction.
- - The Δalr mutant enhanced inflammation and immune activation in macrophages through the TLR4-NF-κB-NLRP3 signaling pathway, leading to reduced Brucella survival and showing lower toxicity combined with stronger immunogenicity.
Persister cells are transiently tolerant to antibiotics and are associated with recalcitrant chronic infections due to recolonization of host cells after antibiotic removal. spp. are facultative pathogens that establish intracellular infection cycles in host cells which results in chronic persistent infections.
View Article and Find Full Text PDF