Regulating Mitochondrial Aging via Targeting the Gut-Bone Axis in BMSCs With Oral Hydrogel Microspheres to Inhibit Bone Loss.

The gut-bone axis is a promising target for osteoporosis treatment, yet existing delivery systems lack precise targeting. Herein, an oral hydrogel microsphere system (E7-Lipo@Alg/Cs) is developed using gas microfluidic and ionic crosslinking technologies to deliver drugs to bone marrow mesenchymal stem cells (BMSCs) via the gut-bone axis, regulating mitochondrial aging. A BMSC-affine peptide is conjugated onto liposomes encapsulating Fisetin, followed by incorporation into alginate-calcium hydrogel microspheres.

Efficacy of endoscopic interlaminar decompression in lumbar spinal stenosis: a retrospective study.

This retrospective study evaluated the clinical effectiveness of endoscopic interlaminar decompression for lumbar spinal stenosis in 40 patients treated from February 2020 to January 2022. The procedure was successful in all cases, with only one dural sac injury reported and no other complications. Postoperative Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA) scores improved significantly (P<0.

Endoscopic double line suture repair technique for repairing Iatrogenic dural tear: a technical case report.

Purpose: Introducing a suture repair technology, endoscopic double line suture repair technique, for iatrogenic dural injury during Percutaneous Endoscopic Lumbar Discectomy (PELD) surgery.

Methods: A patient with dural injury and cauda equina herniation during PELD surgery was treated with endoscopic double line suture repair technique.

Results: A patient with dural injury and cauda equina nerve herniation during PELD surgery was successfully treated using double-line suture technique.

Casticin induces ferroptosis in human osteosarcoma cells through Fe overload and ROS production mediated by HMOX1 and LC3-NCOA4.

Osteosarcoma is a primary solid bone malignancy, and surgery + chemotherapy is the most commonly used treatment. However, chemotherapeutic drugs can cause a range of side effects. Casticin, a polymethoxyflavonoid, has anti-tumor therapeutic effects.

Evaluation of parallel endplate osteotomy for severe rigid spinal deformities: a retrospective analysis of 36 cases with a minimum 2-year follow-up.

Background: To report on the technique and results of parallel endplate osteotomy (PEO) for severe rigid spinal deformity.

Methods: We retrospectively reviewed the clinical data of 36 patients with severe rigid spinal deformities who underwent PEO between July 2016 and December 2018 and who were followed up for at least 24 months.

Results: Following PEO, the kyphosis and scoliosis correction rates reached 77.

CRISPR/dCas9-Mediated Parkin Inhibition Impairs Mitophagy and Aggravates Apoptosis of Rat Nucleus Pulposus Cells Under Oxidative Stress.

Objective: The aim of this study is to explore the role of Parkin in intervertebral disk degeneration (IDD) and its mitophagy regulation mechanism.

Study Design And Methods: Rat nucleus pulposus (NP) cells were stimulated with hydrogen peroxide (HO) to a mimic pathological condition. Apoptosis and mitophagy were assessed by Western blot, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, and immunofluorescence staining.

Protection of L1 nerve roots by pre-relieve tension in parallel endplate osteotomy for severe rigid thoracolumbar spine deformity.

Background: This is a retrospective study of the use of parallel endplate osteotomy (PEO) for correction of severe rigid thoracolumbar spine deformity.

Methods: From July 2016 to January 2019, 12 patients with severe rigid thoracolumbar spine deformity underwent PEO on T12 or L1 vertebrae were studied.

Results: Following PEO at T12 or L1, the mean kyphosis and scoliosis correction rates reached 77.

Management of Spine Tuberculosis With Chemotherapy and Percutaneous Pedicle Screws in Adjacent Vertebrae: A Retrospective Study of 34 Cases.

Study Design: Retrospective study.

Objective: The objective of this study was to evaluate the efficacy of local chemotherapy combined with percutaneous pedicle screw in adjacent vertebra in the treatment of spine tuberculosis (TB).

Summary Of Background Data: Despite the increased treatment concepts and surgical methods, the management of TB, which is increasing in prevalence, remains challenging.

[Long-term clinical studies on the treatment of lumbosacral spinal tuberculosis with CT-guided minimally invasive surgery].

Objective: To evaluate the clinical effects of CT-guided percutaneous puncture and local chemotherapy for lumbosacral spinal tuberculosis.

Methods: From January 2002 to March 2013, 145 patients (84 males and 61 females) with lumbosacral spinal tuberculosis underwent failed conservative treatment were treated with CT-guided minimally invasive surgery. Their clinical data were retrospectively analyzed.

Outcomes of percutaneous endoscopic lumbar discectomy via a translaminar approach, especially for soft, highly down-migrated lumbar disc herniation.

Purpose: This study reports a new approach for percutaneous endoscopic lumbar iscectomy (PELD), especially for soft, highly down-migrated lumbar disc herniation.

Methods: Seven patients with soft, highly down-migrated lumbar disc herniation who underwent PELD via a translaminar approach under local anaesthesia from January 2013 to June 2015, including five patients who underwent failed PELD in other hospitals, were retrospectively analyzed. Clinical outcomes were evaluated according to pre-operative and post-operative visual analogue scale (VAS) scores, Oswestry disability index (ODI) scores and post-operative magnetic resonance imaging (MRI).

Limited long-segment fusion for degenerative lower lumbar scoliosis: a special kind of scoliosis.

Aim: The aim of the study was to investigate the feasibility of limited long-segment fusion for a special kind of scoliosis: degenerative lower lumbar scoliosis without severe thoracolumbar kyphosis.

Methods: A total of 43 patients with degenerative lower lumbar scoliosis who underwent spinal surgery at our hospital from June 2003 to September 2012 were included in this retrospective study. The apical vertebrae included L3 and L4, the end vertebra was L2 or L3, and the T10-L2 kyphosis angle was <20°.