Improved new bone formation capacity of hyaluronic acid-bone substitute compound in rat calvarial critical size defect.

Background: Bone loss of residual alveolar ridges is a great challenge in the field of dental implantology. Deproteinized bovine bone mineral (DBBM) is commonly used for bone regeneration, however, it is loose and difficult to handle in clinical practice. Hyaluronic acid (HA) shows viscoelasticity, permeability and excellent biocompatibility.

Prediction of hepatic artery occlusion after liver transplantation by ultrasound characteristics and clinical risk factors.

Background: Hepatic artery occlusion (HAO) after liver transplantation (LT) is a devastating complication, resulting in early graft loss and reduced overall survival. Ultrasound is an established assessment method for HAO in patients following LT, especially those with complex hepatic artery reconstruction.

Aim: To investigate the ultrasound characteristics and analyze the risk factors associated with HAO in patients after LT.

Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection.

Herpes simplex virus-1 (HSV-1) infection can cause various diseases and the current therapeutics have limited efficacy. Small interfering RNA (siRNA) therapeutics are a promising approach against infectious diseases by targeting the viral mRNAs directly. Recently, we employed a novel tRNA scaffold to produce recombinant siRNA agents with few natural posttranscriptional modifications.

Accuracy of dynamic navigation compared to static surgical guides and the freehand approach in implant placement: a prospective clinical study.

Background: Computer-guided implant surgery has improved the quality of implant treatment by facilitating the placement of implants in a more accurate manner. This study aimed to assess the accuracy of implant placement in a clinical setting using three techniques: dynamic navigation, static surgical guides, and freehand placement. We also investigated potential factors influencing accuracy to provide a comprehensive evaluation of each technique's advantages and disadvantages.

Accuracy analysis of robotic-assisted immediate implant placement: A retrospective case series.

Objectives: This study aimed to investigate the accuracy of a robotic computer-assisted implant surgery (r-CAIS) for immediate implant placement.

Methods: Patients requiring immediate implant placement in the maxillary anterior region were enrolled for r-CAIS. Before surgery, the patients underwent a cone beam computed tomography (CBCT) scan with a positioning marker.

A novel approach in biomedical engineering: The use of polyvinyl alcohol hydrogel encapsulating human umbilical cord mesenchymal stem cell-derived exosomes for enhanced osteogenic differentiation and angiogenesis in bone regeneration.

Developing effective methods for alveolar bone defect regeneration is a significant challenge in orthopedics. Exosomes from human umbilical cord mesenchymal stem cells (HUMSC-Exos) have shown potential in bone repair but face limitations due to undefined application methods and mechanisms. To address this, HUMSC-Exos were encapsulated in polyvinyl alcohol (PVA) hydrogel (Exo@PVA) to create a novel material for alveolar bone repair.

Tanreqing injection inhibits influenza virus replication by promoting the fusion of autophagosomes with lysosomes: An integrated pharmacological study.

Ethnopharmacological Relevance: Tanreqing injection (TRQ) is widely used, traditional Chinese medicine (TCM) injection used in China to treat respiratory infections. Modern pharmacological studies have confirmed that TRQ can protect against influenza viruses. However, the mechanism by which TRQ inhibits influenza viruses remains unclear.

Prognostic value of ultrasound in early arterial complications post liver transplant.

Liver transplantation is the primary therapeutic intervention for end-stage liver disease. However, vascular complications, particularly those involving the hepatic artery, pose significant risks to patients. The clinical manifestations associated with early arterial complications following liver transplantation are often nonspecific.

N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA.

Epitranscriptomic RNA modifications can regulate the stability of mRNA and affect cellular and viral RNA functions. The N4-acetylcytidine (ac4C) modification in the RNA viral genome was recently found to promote viral replication; however, the mechanism by which RNA acetylation in the host mRNA regulates viral replication remains unclear. To help elucidate this mechanism, the roles of N-acetyltransferase 10 (NAT10) and ac4C during the infection and replication processes of the alphavirus, Sindbis virus (SINV), were investigated.

Effects of replacing hybrid giant napier with sugarcane bagasse and fermented sugarcane bagasse on growth performance, nutrient digestibility, rumen fermentation characteristics, and rumen microorganisms of Simmental crossbred cattle.

This study investigated the effects of replacing hybrid giant napiers with sugarcane bagasse and fermented sugarcane bagasse on the growth performance, apparent nutrient digestibility, rumen fermentation characteristics, and rumen microorganisms of Simmental crossbred cattle. Twenty-one Simmental crossbred cattle with similar initial body weight (363.42 ± 8.

PF127 Hydrogel-Based Delivery of Exosomal CTNNB1 from Mesenchymal Stem Cells Induces Osteogenic Differentiation during the Repair of Alveolar Bone Defects.

Pluronic F127 (PF127) hydrogel has been highlighted as a promising biomaterial for bone regeneration, but the specific molecular mechanism remains largely unknown. Herein, we addressed this issue in a temperature-responsive PF127 hydrogel loaded with bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (Exos) (PF127 hydrogel@BMSC-Exos) during alveolar bone regeneration. Genes enriched in BMSC-Exos and upregulated during the osteogenic differentiation of BMSCs and their downstream regulators were predicted by bioinformatics analyses.

An algal lectin griffithsin inhibits Hantaan virus infection and .

Hantaan virus (HTNV) is the etiological pathogen of hemorrhagic fever with renal syndrome in East Asia. There are currently no effective therapeutics approved for HTNV and other hantavirus infections. We found that griffithsin (GRFT), an algae-derived lectin with broad-spectrum antiviral activity against various enveloped viruses, can inhibit the growth and spread of HTNV.

Structural variation and evolution of chloroplast in green algae.

As one of the important groups of the core Chlorophyta (Green algae), Chlorophyceae plays an important role in the evolution of plants. As a carrier of amino acids, plays an indispensable role in life activities. However, the structural variation of chloroplast and its evolutionary characteristics in Chlorophyta species have not been well studied.

Simultaneous Temperature and Strain Measurements Using Polarization-Maintaining Few-Mode Bragg Gratings.

Simultaneous measurement of temperature and strain was demonstrated using a polarization-maintaining few-mode Bragg grating (PM-FMF-FBG) based on the wavelength and phase modulation of the even L P 11 mode. The wavelength shift sensitivity and the interrogated phase sensitivity of the temperature and strain were measured to be 10 pm·°C and 0.73 pm·με and -3.

Measurement of effective nonlinear coefficients in few-mode fibers.

Because of random mode coupling, the nonlinear coefficient in few-mode fibers (FMFs) is averaged to an effective value, which can be theoretically modeled and calculated by using the multi-mode Manakov equations. In this Letter, we experimentally measure the effective nonlinear coefficients in a 530-m-long FMF supporting two mode groups, namely, the $ {\rm LP}_{01} $LP and $ {\rm LP}_{11} $LP mode groups, by exploiting the self-phase and cross-phase modulations of pulsed fields. By using the nonlinear coefficient of the $ {\rm LP}_{01} $LP mode as a reference and comparing the spectral broadening of the pulsed fields, we obtain the intra-modal effective nonlinear coefficient of the $ {\rm LP}_{11} $LP mode and the inter-modal effective nonlinear coefficient between the $ {\rm LP}_{01} $LP and $ {\rm LP}_{11} $LP modes.

Investigation of the Pressure Gain Characteristics and Cycle Performance in Gas Turbines Based on Interstage Bleeding Rotating Detonation Combustion.

To further improve the cycle performance of gas turbines, a gas turbine cycle model based on interstage bleeding rotating detonation combustion was established using methane as fuel. Combined with a series of two-dimensional numerical simulations of a rotating detonation combustor (RDC) and calculations of cycle parameters, the pressure gain characteristics and cycle performance were investigated at different compressor pressure ratios in the study. The results showed that pressure gain characteristic of interstage bleeding RDC contributed to an obvious performance improvement in the rotating detonation gas turbine cycle compared with the conventional gas turbine cycle.

[Research on the intervention of Yishen Huoxue prescription to renal fibrosis through the signal regulation by microRNA-126 to VEGF-Notch].

Objective: To explore the molecular mechanism of Yishen Huoxue prescription in delaying the development of renal fibrosis by regulating the microRNA-126/vascular endothelial growth factor-Notch (miR-126/VEGF-Notch) signaling pathway.

Methods: Ninety male Sprague-Dawley (SD) rats were randomly divided into sham operation group (sham group), unilateral ureteral obstruction (UUO) model group, losartan group (50 mg×kg×d) and high, medium and low doses Yishen Huoxue prescription group (25.2, 12.

Contrast-enhanced transthoracic echocardiography applied in evaluation of pulmonary right-to-left shunt: A preliminary study.

Objective: To investigate the detection rate of patent foramen ovale-right to left shunt (PFO-RLS) and/or pulmonary-right to left shunt (P-RLS) via contrast-enhanced transthoracic echocardiography (c-TTE) in healthy participants, patients suffering from cryptogenic stroke and migraine with aura.

Methods: Initially, 20 healthy volunteers, 21 cases with cryptogenic stroke, and 18 cases with migraine aura were randomly selected, and all of them received c-TTE and transesophageal echocardiography (TEE) examinations. First of all, 0.

21 spatial mode erbium-doped fiber amplifier for mode division multiplexing transmission.

We experimentally demonstrate a 12-mode group (21 spatial mode) cladding-pumped few-mode erbium-doped fiber amplifier. The differential modal gain (DMG) is dramatically reduced by using the double cladding erbium-doped fiber (DC-EDF) with a refractive index trench structure, which helps to tightly confine all 21 spatial modes in the core and to mitigate the bending loss. Our experimental results show that the DMG gain is about 3 dB when the average signal modal gain for all 12 mode groups is up to 15 dB across the C-band.

Experiment and Artificial Neural Network Prediction of Thermal Conductivity and Viscosity for Alumina-Water Nanofluids.

To effectively predict the thermal conductivity and viscosity of alumina (Al₂O₃)-water nanofluids, an artificial neural network (ANN) approach was investigated in the present study. Firstly, using a two-step method, four Al₂O₃-water nanofluids were prepared respectively by dispersing different volume fractions (1.31%, 2.

Transformation of erythromycin during secondary effluent soil aquifer recharging: Removal contribution and degradation path.

Erythromycin (ERY), a widely used antibiotic, has recently been detected in municipal secondary effluents and poses serious threats to human health during wastewater reusing. In this study, the removal, fate, and degradation pathway of ERY in secondary effluent during soil aquifer treatment was evaluated via laboratory-scale SAT tests. Up to a 92.

Rayleigh scattering in few-mode optical fibers.

The extremely low loss of silica fibers has enabled the telecommunication revolution, but single-mode fiber-optic communication systems have been driven to their capacity limits. As a means to overcome this capacity crunch, space-division multiplexing (SDM) using few-mode fibers (FMF) has been proposed and demonstrated. In single-mode optical fibers, Rayleigh scattering serves as the dominant mechanism for optical loss.

Adsorption of Cu and Zn by extracellular polymeric substances (EPS) in different sludges: Effect of EPS fractional polarity on binding mechanism.

Extracellular polymeric substances (EPS) in sludge samples played a major role in heavy metals removal during wastewater treatment. In this study, the binding quality, adsorption mechanism, as well as the chemical fractional contribution of the sludge EPS from activated sludge, anaerobic granular sludge and anaerobic flocculent sludge to the adsorption of Zn and Cu was investigated. For all three sludge samples, Cu could be more easily adsorbed than Zn, and EPS extracted from the anaerobic granular sludge exhibited a relatively higher adsorption capacity than that of anaerobic flocculent sludge and activated sludge.

Transformation and speciation of typical heavy metals in soil aquifer treatment system during long time recharging with secondary effluent: Depth distribution and combination.

Soil aquifer treatment (SAT) systems rely on extensive physical and biogeochemical processes in the vadose zone and aquifer for water quality improvement. In this study, the distribution, quantitative changes, as well as the speciation characteristics of heavy metals in different depth of soils of a two-year operated lab-scale SAT was explored. A majority of the heavy metals in the recharged secondary effluent were efficiently trapped by the steady-state operated SAT (removal efficiency ranged from 74.

Influences of Schneiderian membrane conditions on the early outcomes of osteotome sinus floor elevation technique: a prospective cohort study in the healing period.

Objectives: To radiographically investigate early outcomes of osteotome sinus floor elevation in the healing phase utilizing cone beam computed tomography and evaluate influences of Schneiderian membrane conditions.

Material And Methods: One hundred patients were consecutively recruited for osteotome sinus floor elevation (OSFE) surgery using deproteinized bone mineral. CBCT was taken prior to (T0), immediately post-operatively (T1), and after the healing period (T2).