Publications by authors named "Ning-Xi Wang"
Int J Mol Sci
August 2022
Article Synopsis
- A-to-I RNA editing and mA modification are crucial RNA modifications influencing gene expression and tumor development in mammals, but their interaction in cancer needs more exploration.
- This study reveals that the enzyme ADAR1 boosts the protein level of METTL3, promoting the growth and spread of breast cancer cells through a link with YTHDF1.
- The research shows that both ADAR1 and METTL3 are elevated in breast cancer samples, and the presence of ADAR1 enhances METTL3, leading to changes that facilitate tumor progression.
Cell Transplant
February 2022
Article Synopsis
- MsrB1 is an enzyme involved in converting sulfoxides back to methionine and is found to be highly expressed in colorectal cancer (CRC) tissues and cell lines.
- MsrB1 knockdown in CRC cell lines led to decreased cell proliferation, migration, and invasion, while increasing apoptosis and altering protein levels related to cell adhesion and epithelial-mesenchymal transition.
- The study suggests that MsrB1 influences CRC tumorigenesis through the GSK-3β/β-catenin signaling pathway, highlighting its potential as a biomarker and therapeutic target for CRC treatment.
