ARF6 promotes Streptococcus suis suilysin induced apoptosis in HBMECs.

Streptococcus suis (S. suis) is a significant zoonotic microorganism that causes a severe illness in both pigs and humans and is characterized by severe meningitis and septicemia. Suilysin (SLY), which is secreted by S.

Efficacy of Traditional Chinese Medicine on COVID-19: Two Case Reports.

Severe acute respiratory syndrome coronavirus 2-infected pneumonia (novel coronavirus-infected pneumonia [NCIP]) is a new viral illness initially identified in the central Chinese city of Wuhan in December 2019. According to the daily report on the epidemic situation of coronavirus disease (COVID-19) issued by the National Health and Family Planning Commission of the People's Republic of China on March 23, 2020: COVID-19 is highly infectious, causing extremely high incidence of NCIP throughout Wuhan and has spread swiftly to 34 provinces within China and >100 other countries around the world between January and March 2020. Up to August 11, 2020, there have been 89,383 cases diagnosed as coronavirus-infected pneumonia; and 4,696 deaths in China (mortality rate of 5.

Correction: LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics.

[This corrects the article DOI: 10.18632/oncotarget.22759.

The nuclear GSK-3β regulated post-transcriptional processing of mRNA through phosphorylation of SC35.

Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine kinase and regulates a variety of biological processes. Recent studies show GSK-3β can regulate pre-mRNA processing and transcription through phosphorylation of multiple splicing factors, but the detailed mechanism is still undetermined. In this study, we further proved that GSK-3β could specifically co-localize with SC35 in nuclear speckles depending on its kinase activity.

[ADS-J1 antagonizes semen-derived enhancer of virus infection-mediated enhancement of transmitted founder HIV-1 and its matched chronic control strain infection].

Objective: To investigate the effect of semen-derived enhancer of virus infection (SEVI) on the infection of transmitted/founder (TF) HIV-1 and its matched chronic control (CC) viruses and the antagonism of ADS-J1 on SEVI-mediated enhancement of TF and CC virus infection in vitro.

Methods: PAP self-assembling into SEVI amyloid fibrils was validated by ThT assay. We generated the virus stocks of TF and CC virus pair.

LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics.

Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in development and progression of colorectal cancer. Recently, dysregulation of LRP6 has proved to be involved in the progression of cancers, but its biological role and clinical significance in colorectal cancer remain unclear. In present study, we revealed that phosphorylation of LRP6 was aberrantly upregulated in colorectal carcinoma correlating with TNM or Dukes staging and worse prognosis.

[Prokaryotic expression of recombinant human bone morphogenetic protein-2 and preparation of monoclonal antibodies].

Objective: To express and purify the recombinant human bone morphogenetic protein-2 mature peptide (rhBMP-2m) in prokaryotic system and to develop highly-specific monoclonal antibodies.

Methods: An engineered E. coli strain expressing rhBMP-2m was fermented.

[Effects of long-term fertilization on soil enzyme activities and soil physicochemical properties of facility vegetable field].

An investigation was made on a long-term fertilization facility vegetable field at Shenyang Agricultural University to study the effects of long-term fertilization on the soil enzyme activities and soil physicochemical properties. Long term application of organic manure combined with or without nitrogen fertilizer increased the contents of soil organic matter, N, P, and K, and improved the soil physical properties and soil invertase, urease, and neutral phosphatase activities. However, long-term application of nitrogen fertilizer alone decreased soil pH and soil enzymes activities.