Publications by authors named "Ning-Jen Chung"
Cumulative Dose Effects of H1 Antihistamine Use on the Risk of Dementia in Patients With Allergic Rhinitis.
J Allergy Clin Immunol Pract
August 2024
Background: H1 antihistamines (AHs), categorized as first-generation antihistamines (FGAs) or second-generation antihistamines (SGAs), possess anticholinergic properties linked to heightened dementia risk.
Objectives: To explore dementia risk in patients with allergic rhinitis using AHs.
Methods: Taiwanese patients with new-onset allergic rhinitis (2011-2017) constituted the study population (677,971 with FGAs or SGAs, 36,081 without AHs).
Recent studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) who receive metformin have a decreased risk of developing age-related macular degeneration (AMD). However, other studies have also suggested that metformin may increase the risk of AMD development. Therefore, this study investigated the association between treatment with metformin and the risk of AMD in patients with T2DM by using Taiwan' National Health Insurance Research Database.
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- - The study examined the relationship between metformin use and dementia risk in diabetes patients, using data from those diagnosed between 2002 and 2013.
- - Findings revealed that lower doses of metformin (cumulative defined daily dose < 300) were associated with a reduced risk of dementia, while higher doses and intensities did not show similar protective effects.
- - The authors suggest that more clinical trials are needed to explore the mechanisms linking metformin dosage to dementia risk.
Article Synopsis
- This study focused on the risk of developing pneumonia (PJP) among solid organ transplant (SOT) recipients, finding that they are significantly more at risk compared to non-transplant individuals.
- Over a 3-year period, SOT recipients had an adjusted odds ratio (aOR) of 17.18 for developing PJP, with higher risks noted at 6 months, 1 year, and 2 years post-transplant.
- Patients with additional health issues such as HIV, hematological malignancies, or vasculitis were identified as being at even greater risk of PJP after receiving an organ transplant.
Background And Aims: Studies have demonstrated that the short-term use of metformin benefits liver function among patients with type 2 diabetes mellitus (T2DM). However, few studies have reported on the effects of long-term metformin treatment on liver function or liver histology. This study investigated the correlation between metformin use and the incidence of nonalcoholic fatty liver disease (NAFLD) among patients with T2DM.
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