Publications by authors named "Ning-Fang Lian"
Purpose: Circular RNAs (circRNAs) are recently identified as a class of non-coding RNAs that participate in the incidence of acute myocardial infarction (AMI). However, circRNAs expression pattern in obstructive sleep apnea (OSA) with AMI remains unknown. The aim was to investigate circRNAs expression alteration in serum exosomes derived from OSA patients with AMI.
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- Patients with obstructive sleep apnoea (OSA) face significant damage to their blood vessels, primarily due to a condition called chronic intermittent hypoxia (CIH).
- The study examined how CIH impacts human vein endothelial cells by monitoring cell health, mitochondrial function, and specific protein expressions.
- Findings revealed that CIH led to decreased cell viability and increased cell death, but treatments with certain drugs improved cell survival and mitochondrial health, indicating that a protein called PPARγ plays a critical role in these protective processes.
Exhausting T Cells During HIV Infection May Improve the Prognosis of Patients with COVID-19.
Front Cell Infect Microbiol
October 2021
T-cell reduction is an important characteristic of coronavirus disease 2019 (COVID-19), and its immunopathology is a subject of debate. It may be due to the direct effect of the virus on T-cell exhaustion or indirectly due to T cells redistributing to the lungs. HIV/AIDS naturally served as a T-cell exhaustion disease model for recognizing how the immune system works in the course of COVID-19.
View Article and Find Full Text PDF[Ventilatory and hemodynamic effects of continuous positive airway pressure in dogs with acute cardiogenic pulmonary edema].
Zhonghua Jie He He Hu Xi Za Zhi
June 2005
Objective: To investigate the ventilatory and hemodynamic effects of continuous positive airway pressure (CPAP) in acute cardiogenic pulmonary edema (ACPE) in dogs.
Methods: Cardiac output (CO), heart rate (HR), blood pressure (BP), pulmonary artery wedge pressure (PAWP), central venous pressure (CVP) and intrathoracic negative pressure (Pt) were measured. These parameters were recorded at spontaneous breath, 5 cm H2O, 10 cm H2O, and 15 cm H2O CPAP in ten dogs before (healthy state) and after the induction of ACPE.