Publications by authors named "Ning-Chen An"
Neural Regen Res
April 2021
Article Synopsis
- The blood-spinal cord barrier is crucial for recovery after spinal cord injuries, yet its impact on neurovascular units is often overlooked in research.
- In experiments using mouse models, administration of platelet-derived growth factor reduced neuronal damage, improved locomotor function, and enhanced collagen synthesis while limiting harmful astrocyte proliferation and autophagy-related apoptosis.
- In vitro studies revealed that platelet-derived growth factor positively affects endothelial cells related to the blood-spinal cord barrier by reducing autophagy, and its benefits can be negated by using an autophagy inhibitor prior to injury.
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