Relationship between systemic immune-inflammation index and long-term all-cause and cause-specific mortality among adult asthma patients: a population-based study.

Background: Persistent inflammation in the airways is a hallmark of asthma, and researchers have extensively explored various inflammatory indicators that contribute to the condition. Despite this, there is limited research on the relationship between the systemic immune-inflammation index (SII), a novel marker of inflammation, and overall mortality rates as well as mortality rates due to specific causes in individuals with asthma.

Methods: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) covering a 20-year period, from 1999 to 2018.

Development of A Low-Dose Strategy for Propagation-based Imaging Helical Computed Tomography (PBI-HCT): High Image Quality and Reduced Radiation Dose.

Propagation-based imaging computed tomography (PBI-CT) has been recently emerging for visualizing low-density materials due to its excellent image contrast and high resolution. Based on this, PBI-CT with a helical acquisition mode (PBI-HCT) offers superior imaging quality (e.g.

Se-S dynamic exchange reaction: a strategy of highly efficient S-S bond cleavage for synthesizing benzothiazole derivatives.

We report a Se-S dynamic exchange reaction as a methodology for highly efficient S-S bond cleavage. In this study, a NaSe-disulfide dynamic exchange reaction has been demonstrated for the first time and the strategy has been employed in the preparation of benzothiazole derivatives, demonstrating highly efficient S-S bond cleavage, lowered dosage of the S-S bond cleaving reagent, good tolerance toward various substituents and excellent yields. It is envisaged that the concept of metal selenide-disulfide dynamic interchange reaction is a general avenue for synthesizing sulfur-containing heterocycles.

Identification of hub genes and biological pathways related to central post-stroke pain in ischemic stroke.

This investigation aims to screen ischemic stroke (IS)-related hub genes of central post-stroke pain (CPSP) from public databases and predict their potential roles through bioinformatics analysis to better interpret CPSP in IS. First, based on differential analysis, Venn analysis, and enrichment analyses, we identified 13 differently expressed genes in CPSP (CPSP-DEGs) related to the TNF signaling pathway, Vascular smooth muscle contraction, and IL-17 signaling pathway. Subsequently, through screening and analysis of the PPI network constructed by the Search Tool for the Retrieval of Interacting Genes (STRING) database, we obtained 3 CPSP-related hub genes (CD163, MMP9, and ARG1).

The diagnostic value of metagenomic next-generation sequencing in suspected pulmonary tuberculosis patients with scarce sputum or negative sputum etiological test results.

Objective: To compare the diagnostic value between mNGS and conventional tests in suspected pulmonary tuberculosis (PTB) patients with scarce sputum or with negative sputum etiological test results.

Methods: We enrolled eligible patients admitted to our department from 2018 to 2021. Their bronchoalveolar lavage fluid (BALF) and lung biopsy tissue samples were sent for mNGS and conventional tests.

Case report: Vein of Marshall-catheter ablation combined with left atrial appendage occlusion for treatment of atrial fibrillation.

The utilization of the one-stop strategy for treating atrial fibrillation (AF) has been on the rise, but the combination of vein of Marshall catheter ablation with left atrial appendage occlusion has been rarely reported. In this case, a 62-year-old man with persistent AF underwent a one-stop strategy that included ethanol infusion in the vein of Marshall, radiofrequency catheter ablation, and left atrial appendage occlusion. The procedures successfully achieved ablation in the vein of Marshall, pulmonary vein isolation, and left atrial appendage occlusion.

Characterization of hydrogel-scaffold mechanical properties and microstructure by using synchrotron propagation-based imaging.

Hydrogel-based scaffolds have been widely used in soft tissue regeneration due to their biocompatible and tissue-like environment for maintaining cellular functions and tissue regeneration. Understanding the mechanical properties and internal microstructure of hydrogel-based scaffold, once implanted, is imperative in tissue engineering applications and longitudinal studies. Notably, this has been challenging to date as various conventional characterization methods by, for example, mechanical testing (for mechanical properties) and microscope (for internal microstructure) are destructive as they require removing scaffolds from the implantation site and processing samples for characterization.

Model analysis for optical frequency comb Faraday modulation rotation spectroscopy.

Modulating the signal is a common method in spectroscopy for reducing noise. However, for broadband coherent light sources like optical frequency combs (OFCs), modulation methods typically involve the use of optical modulators, making the experimental setup cumbersome. This study proposes and successfully implements a broadband Faraday modulation rotation spectroscopy (FAMOS) method combined with an OFC.

Microstructural brain changes following prospective memory rehabilitation in traumatic brain injury: An observational study.

Prospective memory (PM) impairment is a common consequence of moderate-severe traumatic brain injury (TBI). Compensatory strategy training and rehabilitation (COMP) is the usual treatment of PM deficits through environmental modification and the use of assistive methods such as diaries and routines. The study intends to examine the changes in white matter integrity, as measured by advanced diffusion magnetic resonance imaging (dMRI) following COMP intervention in moderate-severe TBI patients.

Online public opinion attention, digital transformation, and green investment: A deep learning model based on artificial intelligence.

The digital economy is rising at an unprecedented pace, becoming a key driver of the comprehensive transformation and upgrading of the global economy and society. Existing research widely demonstrates the multifaceted positive impacts of green investment on corporate development. However, amid the wave of digital transformation, in-depth studies on how digital transformation specifically influences corporate green investment decisions-particularly from the emerging perspective of Online Public Opinion attention-remain insufficient.

Analysis of the relationship between sleep-related disorders and cadmium in the US population.

Background: Cadmium is a heavy metal that accumulates in the body due to environmental and occupational exposure. The neurotoxicity of cadmium received increasingly attention in recent years. Sleeping is regulated and coordinated by nervous system, however, little is known about the relationship between cadmium and sleep.

A novel therapeutic pathway to the human cochlear nerve.

Traditional approaches to the human cochlear nerve have been impeded by its bony encasement deep inside the skull base. We present an innovative, minimally invasive, therapeutic pathway for direct access to the nerve to deliver novel regenerative therapies. Neuroanatomical studies on 10 cadaveric human temporal bones were undertaken to identify a potentially safe therapeutic pathway to the cochlear nerve.

Optimization of extracellular polysaccharides (EPS) production by Stenotrophomonas rhizophila JC1 and its protective effect on alfalfa under Pb stress.

Stenotrophomonas rhizophila JC1 and its extracellular polysaccharides (EPS) have been shown to effectively adsorb heavy metals in previous studies. The fermentation conditions of EPS by S. rhizophila JC1 were optimized using the Box-Behnken design (BBD).

Development and mechanism exploration of a quantitative model for Escherichia coli transformation efficiency based on ultrasonic power.

Ultrasonic-mediated plasmid transformation is a promising microbial transformation strategy with broad application prospects that has attracted interest across various fields. Limited research exists on developing a quantitative model to understand the relationship between transformation efficiency and ultrasonic power. Within the ultrasonic range that did not damage plasmids, the maximum transformation efficiency reached at 4.

Integration of physiology, genomics and microbiomics analyses reveal the biodegradation mechanism of petroleum hydrocarbons by Medicago sativa L. and growth-promoting bacterium Rhodococcus erythropolis KB1.

Despite the effectiveness of microbial-phytoremediation for remediating total petroleum hydrocarbons (TPH)-contaminated soil, the underlying mechanisms remain elusive. This study investigated the whole-genome and biological activity of Rhodococcus erythropolis KB1, revealing its plant growth promotion (PGP), TPH degradation, and stress resistance capabilities. Phytoremediation (using alfalfa) and plant-microbial remediation (using alfalfa and KB1) were employed to degrade TPH.

Enhanced drug release through nitrendipine/hydroxypropyl methylcellulose solid dispersion via supercritical antisolvent technique.

The poor water solubility of nitrendipine (NT) results in low oral bioavailability, which hinders its practical application. Hydroxypropyl methylcellulose (HPMC) is a prominent drug carrier that has been applied in the biomedical field due to its significant characteristics, such as large surface area, biocompatibility and biodegradability. In this study, an efficient drug delivery system based on the preparation of NT/HPMC solid dispersion using supercritical antisolvent (SAS) technology was proposed.

YB06: A Rhizosphere-Genome-Wide Analysis and Plant Growth-Promoting Analysis of a Plant Growth-Promoting Rhizobacterium Isolated from .

, commonly known as Dangshen, is a valuable medicinal plant, but its slow growth and susceptibility to environmental stress pose challenges for its cultivation. In pursuit of sustainable agricultural practices to enhance the yield and quality of Dangshen, the present study isolated a bacterial strain exhibiting plant growth-promoting potential from the rhizosphere of . This strain was subsequently identified as YB06.

RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.

As a RIG-I-like receptor, MDA5 plays a critical role in antiviral innate immunity by acting as a cytoplasmic double-stranded RNA sensor capable of initiating type I interferon pathways. Here, we show that RNF144B specifically interacts with MDA5 and promotes K27/K33-linked polyubiquitination of MDA5 at lysine 23 and lysine 43, which promotes autophagic degradation of MDA5 by p62. Rnf144b deficiency greatly promotes IFN production and inhibits EMCV replication in vivo.

Experimental investigation of dynamic drying in single pharmaceutical granules containing acetaminophen or carbamazepine using synchrotron X-ray micro computed tomography.

Drying time, velocity, and temperature are important aspects of the drying process for pharmaceutical granules observed during tablet manufacturing. However, the drying mechanism of single granules is often limited to modelling and simulation, with the internal and physical changes difficult to quantify at an experimental level. In this study, in-situ synchrotron-based X-ray imaging techniques were used for the first time to investigate the dynamic drying of single pharmaceutical granules, quantifying internal changes occurring over the drying time.