Assessing Wound Healing in Vivo Using a Dual-Function Phosphorescent Probe Sensitive to Tissue Oxygenation and Regenerating Collagen.

Levels of tissue oxygenation and collagen regeneration are critical indicators in the early evaluation of wound healing. Traditionally, these factors have been assessed using separate instruments and different methodologies. Here, we adopt the spatially averaged phosphorescence lifetime approach using Re-diimine complexes (Re-probe) to enable simultaneous quantification of these two critical factors in healing wounds.

A CW-Pumped Dye Nanolaser With an Optimized Nanocavity.

Plasmonic nanolasers, which are promising coherent light sources for integrated photonics, super-resolution imaging, and ultrasensitive sensing applications, face the challenge of high thresholds due to inherent losses in plasmonic nanocavities. While considerable efforts have been made to improve the Q factor, typically quantified by the full width at half maximum (FWHM), intensity (ΔI) is another critical feature of plasmonic resonance. However, the combined influence of both the Q factor and resonance intensity of a plasmonic nanocavity on nanolasing threshold has not been sufficiently explored, as experimentally controlling one variable while keeping the other constant is challenging.

Efficacy of Intraoperative vs Preoperative Indocyanine Green Administration for Near-Infrared Cholangiography During Laparoscopic Cholecystectomy: An Open-Label, Noninferiority, Randomized Controlled Trial.

Background: Near-infrared fluorescence cholangiography improves the clinical effects of laparoscopic cholecystectomy. However, the administration of indocyanine green remains controversial. Both the intraoperative strategy (IS, 0.

Quantification of biomass availability for wood harvesting and storage in the continental United States with a carbon cycle model.

Background: Wood Harvesting and Storage (WHS) is a form of Biomass Carbon Removal and Storage (BiCRS) that utilizes a combined natural and engineered process to harvest woody biomass and put it into long term storage, most frequently in the form of subterranean burial. This paper aims to quantify the availability of woody biomass for the purposes of WHS in the continental United States using a carbon cycle modeling approach. Using a regional version of the VEGAS terrestrial carbon cycle model at 10 km resolution, this paper calculates the annual woody net primary production in the continental United States.

3775-year-old wood burial supports "wood vaulting" as a durable carbon removal method.

Six-times more carbon dioxide (CO) is removed each year by terrestrial photosynthesis than fossil fuel emissions. However, the carbon is mostly returned to the atmosphere by decomposition. We found a 3775-year-old ancient wood log buried 2 meters belowground that was preserved far beyond its expected lifetime.

Dissecting the emerging role of cancer-associated adipocyte-derived cytokines in remodeling breast cancer progression.

Breast cancer has been reported to transcend lung cancer as the most commonly diagnosed cancer in women all over the world. Adipocytes, serving as energy storage and endocrine cells, are the major stromal cells in the breast. Cancer-associated adipocytes (CAAs) are adjacent and dedifferentiated adipocytes located at the invasive front of human breast tumors.

Influence of extreme 2022 heatwave on megacities' anthropogenic CO emissions in lower-middle reaches of the Yangtze River.

An unprecedented heatwave hit the Yangtze River Basin (YRB) in August 2022. We analyzed changes of anthropogenic CO emissions in 8 megacities over lower-middle reaches of the YRB, using a near-real-time gridded daily CO emissions dataset. We suggest that the predominant sources of CO emissions in these 8 megacities are from the power and industrial sectors.

Three-dimensional visualized technology-guided surgical resection for giant hepatic hemangioma with hemorrhagic necrosis: A case report and literature review.

Background: Hepatic hemangioma is the most common type of benign mesenchymal liver tumor and often has a good prognosis. However, giant hepatic hemangioma larger than 10 cm is an unusual event, and accompanying symptoms of internal hemorrhagic necrosis are extremely rare. There are only a few cases reported.

The reduced net carbon uptake over Northern Hemisphere land causes the close-to-normal CO growth rate in 2021 La Niña.

La Niña climate anomalies have historically been associated with substantial reductions in the atmospheric CO growth rate. However, the 2021 La Niña exhibited a unique near-neutral impact on the CO growth rate. In this study, we investigate the underlying mechanisms by using an ensemble of net CO fluxes constrained by CO observations from the Orbiting Carbon Observatory-2 in conjunction with estimates of gross primary production and fire carbon emissions.

Laparoscopic left hemihepatectomy using augmented reality navigation plus ICG fluorescence imaging for hepatolithiasis: a retrospective single-arm cohort study (with video).

Background: Laparoscopic left hemihepatectomy (LLH) has been shown to be an effective and safe method for treating hepatolithiasis primarily affecting the left hemiliver. However, this procedure still presents challenges. Due to pathological changes in intrahepatic duct stones, safely dissecting the hilar vessels and determining precise resection boundaries remains difficult, even with fluorescent imaging.

Evaluation of Low-Cost CO Sensors Using Reference Instruments and Standard Gases for Indoor Use.

CO monitoring is important for carbon emission evaluation. Low-cost and medium-precision sensors (LCSs) have become an exploratory direction for CO observation under complex emission conditions in cities. Here, we used a calibration method that improved the accuracy of SenseAir K30 CO sensors from ±30 ppm to 0.

Rational design and construction of hierarchical porous quasi-hexagonal CoP nanosheets/Co heterostructures as highly efficient bifunctional electrocatalysts for overall water splitting.

Constructing heterostructured electrocatalysts has proven effective in enhancing intrinsic catalytic activity. Herein, under guidance of theoretical calculations, hierarchical porous quasi-hexagonal CoP nanosheets/Co heterostructures supported on carbon cloth (CoP/Co/CC) with a high surface area were rationally designed and elaborately constructed through electroless Co plating, electrochemical oxidation, and phosphidation process, which showed significant electrocatalytic performance toward water electrolysis. Specifically, theoretical calculations revealed that the CoP/Co heterostructure adjusted the electronic structure of CoP and Co, reducing the energy barrier for target reactions and thereby boosting electrocatalytic activities for the hydrogen evolution reaction (HER).

Efficacy of hepatectomy for hepatolithiasis using 3D visualization combined with ICG fluorescence imaging: A retrospective cohort study.

Background: Hepatolithiasis is a complex condition that poses challenges and difficulties in surgical treatment. Three-dimensional visualization technology combined with fluorescence imaging (3DVT-FI) enables accurate preoperative assessment and real-time intraoperative navigation. However, the perioperative outcomes of 3DVT-FI in hepatolithiasis have not been reported.

Impact of three-dimensional reconstruction visualization technology on short-term and long-term outcomes after hepatectomy in patients with hepatocellular carcinoma: a propensity-score-matched and inverse probability of treatment-weighted multicenter study.

Background: Three-dimensional reconstruction visualization technology (3D-RVT) is an important tool in the preoperative assessment of patients undergoing liver resection. However, it is not clear whether this technique can improve short-term and long-term outcomes in patients with hepatocellular carcinoma (HCC) compared with two-dimensional (2D) imaging.

Method: A total of 3402 patients from five centers were consecutively enrolled from January 2016 to December 2020, and grouped based on the use of 3D-RVT or 2D imaging for preoperative assessment.

Weaker regional carbon uptake albeit with stronger seasonal amplitude in northern mid-latitudes estimated by higher resolution GEOS-Chem model.

Terrestrial ecosystem in the Northern Hemisphere is characterized by a substantial carbon sink in recent decades. However, the carbon sink inferred from atmospheric CO data is usually larger than process- and inventory-based estimates, resulting in carbon release or near-neutral carbon exchange in the tropics. The atmospheric approach is known to be uncertain due to systematic biases of coarse atmospheric transport model simulation.

Effect of septal extension graft on nasal tip support: A finite element analysis.

Background: Septal extension graft (SEG) is an effective method to control the projection, rotation, and shape of the nasal tip. However, the structural mechanics of SEG have not yet been adequately determined.

Objectives: The purpose of this study was to examine the effect of SEG parameters on nasal tip support using finite element analysis.

Review and Application of Integrin Alpha v Beta 6 in the Diagnosis and Treatment of Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma.

Integrin Alpha v Beta 6 is expressed primarily in solid epithelial tumors, such as cholangiocarcinoma, pancreatic cancer, and colorectal cancer. It has been considered a potential and promising molecular marker for the early diagnosis and treatment of cancer. Cholangiocarcinoma and pancreatic ductal adenocarcinoma share genetic, histological, and pathophysiological similarities due to the shared embryonic origin of the bile duct and pancreas.

Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering.

Tracheal reconstruction presents a challenge because of the difficulty in maintaining the rigidity of the trachea to ensure an open lumen and in achieving an intact luminal lining that secretes mucus to protect against infection. On the basis of the finding that tracheal cartilage has immune privilege, researchers recently started subjecting tracheal allografts to "partial decellularization" (in which only the epithelium and its antigenicity are removed), rather than complete decellularization, to maintain the tracheal cartilage as an ideal scaffold for tracheal tissue engineering and reconstruction. In the present study, we combined a bioengineering approach and a cryopreservation technique to fabricate a neo-trachea using pre-epithelialized cryopreserved tracheal allograft (ReCTA).

An integrated view of correlated emissions of greenhouse gases and air pollutants in China.

Background: Air pollution in China has raised great concerns due to its adverse effects on air quality, human health, and climate. Emissions of air pollutants (APs) are inherently linked with CO emissions through fossil-energy consumption. Knowledge of the characteristics of APs and CO emissions and their relationships is fundamentally important in the pursuit of co-benefits in addressing air quality and climate issues in China.

CAA-derived IL-6 induced M2 macrophage polarization by activating STAT3.

Background: Tumor-associated macrophages (TAMs) are the most abundant types of immune cells in the tumor microenvironment (TME) of breast cancer (BC). TAMs usually exhibit an M2 phenotype and promote tumor progression by facilitating immunosuppression. This study aimed to investigate the effect of CAA-derived IL-6 on macrophage polarization in promoting BC progression.

Potential genetic therapies based on m6A methylation for skin regeneration: Wound healing and scars/keloids.

Skin wound healing is a complex and multistage process, where any abnormalities at any stage can result in the accumulation of non-functional fibrotic tissue, leading to the formation of skin scars. Epigenetic modifications play a crucial role in regulating gene expression, inhibiting cell fate determination, and responding to environmental stimuli. m6A methylation is the most common post-transcriptional modification of eukaryotic mRNAs and long non-coding RNAs.