Mechanistic applications of low-temperature plasma in starch-based biopolymer film: A review.

The substitution of traditional packaging with bio-based edible films has emerged as a new research direction. The starch biopolymer films currently studied by researchers exhibit issues such as inadequate physical properties, barrier performance, mechanical strength, and biological activity. Consequently, a range of advanced techniques are employed to enhance the properties of biopolymer films.

From microbial perspective: Manufacturing process, chemical composition and health benefis of Liupao tea-A comprehensive review.

Liupao tea (LPT) has garnered increasing attention from researchers due to its distinctive flavor, its role in traditional Chinese medicine for dispelling dampness and promoting health, and its rich cultural heritage. Over the past decade, studies have explored the chemical composition, biological activity, taste profile, microbial community, and safety aspects of LPT. However, a comprehensive understanding of the intricate relationships between LPT, its associated microorganisms, characteristic chemical components, and biological activities remains lacking.

Using Natural Language Processing (NLP) Methods to Predict Topics Included in 2019 Ohio Syphilis Disease Intervention Specialist (DIS) Records.

Background: Free-text notes in disease intervention specialist (DIS) records may contain relevant information for STI control. In their current form, the notes are not analyzable without manual reading, which is labor-intensive and prone to error.

Methods: We used natural language processing (NLP) methods to analyze 2019 Ohio DIS syphilis records with non-missing notes (n = 1,987).

Ultrafine Particulate Matter Exacerbates the Risk of Delayed Neural Differentiation: Modulation Role of METTL3-Mediated mA Modification.

Air pollution, especially from ultrafine particles (PM, ≤0.1 μm), is increasingly recognized for its detrimental effects on health. The influence of PM on neurodevelopmental disorders and its underlying mechanisms remain incompletely understood but are of significant concern.

Di (2-ethylhexyl) phthalate reduces sperm motility by decreasing sperm tail energy supply.

Di (2-ethylhexyl) phthalate (DEHP) is widespread in the environment. It can impair sperm function through damaging the sperm development process. However, few studies have focused on the sperm tail that is directly related to sperm motility.

Citric Acid Improves Egg White Protein Foaming Characteristics and Meringue 3D Printing Performance.

Meringue has limited the use of meringue for personalization because of its thermally unstable system. Citric acid (CA) enhancement of egg white protein (EWP) foaming properties is proposed for the preparation of 3D-printed meringues. The results showed that CA increased the viscosity, exposure of hydrophobic groups (79.

A Machine Learning Classification Model for Gastrointestinal Health in Cancer Survivors: Roles of Telomere Length and Social Determinants of Health.

Background: Gastrointestinal (GI) distress is prevalent and often persistent among cancer survivors, impacting their quality of life, nutrition, daily function, and mortality. GI health screening is crucial for preventing and managing this distress. However, accurate classification methods for GI health remain unexplored.

Targeting lipid metabolism via nanomedicine: A prospective strategy for cancer therapy.

Lipid metabolism has been increasingly recognized to play an influencing role in tumor initiation, progression, metastasis, and therapeutic drug resistance. Targeting lipid metabolic reprogramming represents a promising therapeutic strategy. Despite their structural complexity and poor targeting efficacy, lipid-metabolizing drugs, either used alone or in combination with chemotherapeutic agents, have been employed in clinical practice.

Nanolabels Prepared by the Entrapment or Self-Assembly of Signaling Molecules for Colorimetric and Fluorescent Immunoassays.

Nanomaterials have attracted significant attention as signal reporters for immunoassays. They can directly generate detectable signals or release a large number of signaling elements for readout. Among various nanolabels, nanomaterials composed of multiple signaling molecules have shown great potential in immunoassays.

Exposure to oxygenated polycyclic aromatic hydrocarbons and endocrine dysfunction: Multi-level study based on hormone receptor responses.

Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of emerging environmental contaminants that exhibit high toxicity compared to parent PAHs. In addition to carcinogenic, teratogenic and mutagenic effects, recent studies show their potential to cause endocrine disruption, but the reports are controversial. In this study, we employed hormone receptors (ERα/AR/GRα/TRβ)-mediated dual luciferase reporter gene assay and molecular docking, and found that five typical OPAHs exhibited agonistic activity towards hormone receptors, and hydrogen bonding and hydrophobic interactions were the primary binding forces involved in OPAHs-receptor interactions.

Multifunctional porphyrin-substituted phenylalanine-phenylalanine nanoparticles for diagnostic and therapeutic applications in Alzheimer's disease.

β-Amyloid (Aβ) peptides are believed as the diagnostic biomarkers and therapeutic targets of Alzheimer's disease (AD). Their complexes with copper ions can catalyze the generation of reactive oxygen species (ROS) to further promote neuronal death. Herein, we suggested that porphyrin-substituted phenylalanine-phenylalanine nanoparticles (TPP-FF NPs) could inhibit the aggregation of Aβ monomers, disassemble the fibrillar Aβ aggregates under light illumination, and depressing the Cu-induced generation of ROS.

Preparation and Characterization of Egg White Protein-Based Composite Edible Coating Containing Thymol Nanoemulsion.

In this study, thymol-loaded nanoemulsion (THYNE) was incorporated into a mixture of egg white protein and hyaluronic acid to prepare antibacterial biopolymer coatings. The oil phase of the nanoemulsion (NE) was prepared by mixing different mass ratios of thymol and corn oil. NE was formed using ultrasonic emulsification, and the physicochemical properties of the NE were investigated.

Prophylactic abdominal drainage versus no-drainage after left pancreatectomy: a systematic review and meta-analysis.

Background: An increasing body of studies indicates that prophylactic abdominal drainage may not be necessary following left pancreatectomy (LP), despite its common use in clinical practice. This meta-analysis seeks to offer a definitive recommendation regarding the necessity of drainage after LP by examining and contrasting postoperative outcomes in patients who did and did not undergo drainage.

Methods: An extensive literature search was conducted to compare the outcomes of no-drainage and drainage after LP from inception to July 2024 on PubMed, MEDLINE, Embase, Web of Science, and the Cochrane Library.

Characterisation of the phytochemical and bioactivity profiles of raw tea, stale-aroma, and betelnut-aroma type of Liupao tea through GC/LC-MS-based metabolomics.

Liupao tea (LPT) is a Chinese dark tea known to possess a unique flavour. Microbial fermentation plays a crucial role in flavour development and enrichment. Currently, the phytochemical profiles and bioactivities of LPT with and without fermentation are not fully known.

Pyrroloquinoline quinone exhibiting peroxidase-mimicking property for colorimetric assays.

Background: Small molecule mimics offer the advantages of easy preparation, good thermodynamic stability, and reproducible catalytic activity. However, most of the reported organic artificial mimics face challenges including low catalytic activity, oxidative self-destruction, and auto-aggregation into inactive dimers. Therefore, novel organic mimics with high catalytic activity as well as good thermal and environmental stability are highly desirable.

Pseudogene KRT17P3 Promotes NSCLC Progression Through Mir-338-3p/USP7/C-Myc.

Background/aim: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality, yet its underlying molecular mechanisms remain poorly understood. Previous research has identified the pseudogene KRT17P3 as a key player in NSCLC chemoresistance, but its functional role in tumor development has not been thoroughly investigated.

Materials And Methods: In this study, we utilized in vitro assays to evaluate the impact of KRT17P3 on NSCLC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT).

log-RRIM: Yield Prediction via Local-to-global Reaction Representation Learning and Interaction Modeling.

Accurate prediction of chemical reaction yields is crucial for optimizing organic synthesis, potentially reducing time and resources spent on experimentation. With the rise of artificial intelligence (AI), there is growing interest in leveraging AI-based methods to accelerate yield predictions without conducting in vitro experiments. We present log-RRIM, an innovative graph transformer-based framework designed for predicting chemical reaction yields.

Electrochemical immunosensors based on the solubility difference of electroactive probe and the dual signal amplification of nanocarrier plus redox cycling.

This work reported a redox cycling system for the design of electrochemical immunosensors by using pyrroloquinoline quinone (PQQ) to promote the oxidation of tris(2-carboxyethyl)phosphine (TCEP). The consumption of TCEP was monitored with ferrocenium (Fc) as the electroactive probe, which was based on the difference in the solubility of Fc with its reduced format (ferrocene, Fc). Metal-organic framework (MOF) was used as the nanocarrier to load biotinylated recognition antibody and PQQ with recombinant streptavidin as the linker.

Preparation and Properties of NaHPO∙12HO/Silica Aerogel Composite Phase Change Materials for Building Energy Conservation.

In this paper, a morphologically stable composite phase change material (CPCM) suitable for use in the field of building energy conservation was developed using NaHPO∙12HO (DHPD) as the phase change material, NaSiO∙9HO (SSNH) as the nucleating agent, and silica aerogel (SA) as the carrier. The results showed that the incorporation of 25 wt% SA resulted in the as-prepared DHPD-SSNH/SA CPCM with a phase change temperature of 30.4 °C, an enthalpy of 163.

Analysis of 2019 Ohio Disease Intervention Specialist Records for Syphilis Cases Using Clustering Algorithms.

Background: Developments in natural language processing and unsupervised machine learning methodologies (e.g., clustering) have given researchers new tools to analyze both structured and unstructured health data.

Ultra-broadband multimode fiber-to-chip edge coupler based on periodically segmented waveguides.

Mode-division multiplexing (MDM) technology demonstrates a bright outlook for enhancing the capacity of chip-scale or fiber-based optical communication. Nevertheless, the fiber-to-chip MDM optical interconnects are hindered by the considerable mode mismatch and inter-modal cross talk between the few-mode fiber (FMF) and on-chip few-mode waveguide (FMW). In this Letter, a new, to the best of our knowledge, multimode coupling solution based on periodically segmented waveguides for the MDM system is proposed, which achieves efficient conversion between LP, LP, and LP modes in FMF and E, E, and E modes in FMW with low refractive index difference.

Overview of the Design and Application of Dual-Signal Immunoassays.

Immunoassays have been widely used for the determination of various analytes in the fields of disease diagnosis, food safety, and environmental monitoring. Dual-signal immunoassays are now advanced and integrated detection technologies with excellent self-correction and self-validation capabilities. In this work, we summarize the recent advances in the development of optical and electrochemical dual-signal immunoassays, including colorimetric, fluorescence, surface-enhanced Raman spectroscopy (SERS), electrochemical, electrochemiluminescence, and photoelectrochemical methods.