Summary of emergency treatment experience of acute severe urethral trauma in pre-pubertal girls.

Purpose: To summarize our treatment experience of acute urethral trauma in pre-pubertal girls.

Methods: We retrospectively analyzed six pre-pubertal girls with acute severe urethral trauma who were admitted to our hospital from April 2003 to April 2023 and followed up.

Results: All six patients had pelvic fractures and vaginal injuries, and one had a rectal injury.

A multifunctional semi-interpenetrating polymer network hydrogel dressing for wound healing.

Hydrogels have exhibited significant application potential in the field of new wound dressings due to their unique physicochemical properties and biological functions. However, traditional hydrogels possess limitations regarding mechanical properties, adhesion, and the promotion of wound healing. Herein, a multifunctional polyvinyl alcohol-tannic acid/polyacrylamide-polydopamine (PVA-TA/PAM-PDA) hydrogels are developed.

Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome.

Background: Doxorubicin (Dox)-induced cardiomyopathy (DIC) is characterized by severe myocardial damage that can progress to dilated cardiomyopathy and potentially lead to heart failure. No effective prevention or treatment strategies are available for DIC. Sauchinone, a diastereomeric lignan isolated from Saururus chinensis, is known for its notable anti-inflammatory effects.

Oxidative stress induced by emerging halohydroxybenzonitrile disinfection byproducts and their binding interaction with catalase.

Halohydroxybenzonitriles (HHBNs) were reported to exist in drinking water as an emerging group of nitrogen-containing aromatic disinfection byproducts (DBPs). The involvement of binding energy with catalase (CAT) as one of molecular descriptors in the quantitative structure-activity relationship model for HHBN cytotoxicity supported that oxidative stress is highly possible to be an essential cytotoxicity mechanism for HHBNs, and the disruption of cellular redox homeostasis may be partly attributed to their interactions towards CAT. However, the relevant evidence is lacking as yet.

Extended Kalman Filtering-Based Nonlinear Model Predictive Control for Underactuated Systems With Multiple Constraints and Obstacle Avoidance.

Underactuated systems are a class of systems in which the number of control inputs is less than the degrees of freedom (DoFs) to be controlled. With the increasing demand for the control performance of underactuated systems, the current research on their optimization of steady-state performance is no longer sufficient. However, owing to limited control inputs, ensuring their transient performance is often difficult.

Confined Carbonization of Pitch Assists the Closed Pore Engineering of Coal-Based Carbon for Superior Na-Ion Storage.

Coal-based carbons have garnered interest as cost-effective anodes for sodium-ion batteries (SIBs) owing to their widespread availability and economic practicality. However, the inherent limitations in their microstructure, including insufficient active sites for Na-ion storage, restrict their potential for high-performance applications. Herein, a pitch-assisted coating treatment through confined carbonization is employed to transform open micropores in coal-based activated carbon into closed pores, resulting in more compact and efficient active sites for Na-ion storage.

Psychometric Properties of Dysphagia Handicap Index Scale for Older Adults with Oropharyngeal Dysphagia in China.

The impact of oropharyngeal dysphagia (OD) on older adults is recognized in Western countries but has not received sufficient attention in China. The dysphagia handicap index (DHI) scale is an OD quality-of-life evaluation instrument. This study evaluated the psychometric properties of the Chinese version of DHI scale in older Chinese adults.

ADFQ-ViT: Activation-Distribution-Friendly post-training Quantization for Vision Transformers.

Vision Transformers (ViTs) have exhibited exceptional performance across diverse computer vision tasks, while their substantial parameter size incurs significantly increased memory and computational demands, impeding effective inference on resource-constrained devices. Quantization has emerged as a promising solution to mitigate these challenges, yet existing methods still suffer from significant accuracy loss at low-bit. We attribute this issue to the distinctive distributions of post-LayerNorm and post-GELU activations within ViTs, rendering conventional hardware-friendly quantizers ineffective, particularly in low-bit scenarios.

Analysis of critical 3D imaging data of surrounding cervical nerves and bone markers in spinal endoscopic surgery.

Determining the relationships among the epiphyseal ring, cervical nerve and vertebral pedicle isthmus via three-dimensional reconstruction can facilitate the precise removal of part of the uncinate process via spinal endoscopy, allowing safe cervical nerve decompression. C-C/T-related indices were measured in 26 patients with cervical spondylotic radiculopathy. The lowest point of epiphyseal ring posterior margin (LPER) was used as the key point for measuring indices, and the following distances were measured around the LPER: the anteroposterior distance from the LPER to the anterior margin of the cervical nerve at the position of the uncinate process tip (ANU), the vertical distance from the LPER to the inferior margin of the cervical nerve at the position of the uncinate process tip (VNU), the vertical distance from the LPER to the cervical nerve superior margin origin (VNS), the vertical distance from the LPER to the cervical nerve inferior margin origin (VNI), the left-right distance from the LPER to the dura mater lateral border (DLB), and the anteroposterior distance from the LPER to the vertebral pedicle isthmus lateral border (PLB).

The effect of irrigation quota on straw decomposition, nitrogen release, and maize nitrogen uptake.

Returning straw to the field can increase soil organic matter content, improve soil physical and chemical properties, enhance soil biological activity, and thus improve soil fertility. However, returning straw to the field has problems such as slow decomposition rate and delayed nutrient release. Reasonable water management is one of the important measures to improve the effectiveness of returning maize straw to the field.

Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer.

In mammalian cells, gene copy number is tightly controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, which promotes cancer progression by drastically increasing the copy number and expression of tumor-promoting genes. For example, in tyrosine kinase inhibitor (TKI)-resistant lung adenocarcinoma (LUAD), oncogene amplification occurs in over 40% of patients' tumors.

Neural Network-Assisted Dual-Functional Hydrogel-Based Microfluidic SERS Sensing for Divisional Recognition of Multimolecule Fingerprint.

To enhance the sensitivity, integration, and practicality of the Raman detection system, a deep learning-based dual-functional subregional microfluidic integrated hydrogel surface-enhanced Raman scattering (SERS) platform is proposed in this paper. First, silver nanoparticles (Ag NPs) with a homogeneous morphology were synthesized using a one-step reduction method. Second, these Ag NPs were embedded in -isopropylacrylamide/poly(vinyl alcohol) (Ag NPs-NIPAM/PVA) hydrogels.

Investigating genetic links between biological aging and adverse pregnancy outcomes.

Observational studies suggest a link between biological aging and adverse pregnancy outcomes (APOs), but causal relationships remain unclear. This study aimed to investigate the relationship between genetically predicted biological aging traits and APOs. Genetic summary statistics from the genome-wide association study (GWAS) of the IEU open GWAS, FinnGen, and meta-analysis were analyzed using Mendelian randomization (MR) to infer causality.

Enhancing Biomass Productivity by Forecast-Informed Pond Operations.

Microalgal cultivation for biofuels and proteins holds significant promise but faces challenges in achieving economically viable biomass productivity under variable environmental conditions. This study introduces a forecast-informed pond operation (FIPO) system that uses numerical weather prediction (NWP) ensemble forecasts and the biomass assessment tool (BAT) to optimize daily dilution rates for enhanced biomass production. In contrast to the current practice, where fixed dilution rates are based on operator experience, the FIPO system determines the optimal dilution rate based on future weather forecasts and biomass growth conditions.

Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation.

Hepatitis B virus (HBV) relaxed circular DNA (rcDNA) possesses an 8-9 nucleotide-long terminal redundancy (TR, or r) on the negative (-) strand DNA derived from the reverse transcription of viral pregenomic RNA (pgRNA). It remains unclear whether the TR forms a 5' or 3' flap structure on HBV rcDNA and which TR copy is removed during covalently closed circular DNA (cccDNA) formation. To address these questions, a mutant HBV cell line HepDES-C1822G was established with a C1822G mutation in the pgRNA coding sequence, altering the sequence of 3' TR of (-) strand DNA while the 5' TR remained wild type (wt).

Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer.

We here investigate the expression of the mitochondrial carrier homolog 2 (MTCH2) and its potential function in castration-resistant prostate cancer (CRPC). Bioinformatic analyses reveal that MTCH2 overexpression is associated with critical clinical parameters of prostate cancer. Single-cell sequencing data indicate elevated MTCH2 expression in the prostate cancer epithelium.

Clinical characteristics, complications and satisfaction of megameatus intact prepuce (MIP) hypospadias variant: a 15 year retrospective study.

Background: To analyze the clinical characteristics, complications and patients satisfaction of MIP hypospadias variant.

Methods: A retrospective analysis was performed for 31 patients with MIP admitted to our hospital from January 2008 to February 2023. All enrolled patients underwent telephone follow-up and a survey was conducted on the satisfaction of patients and their families.

Chick Early Amniotic Fluid Alleviates Dextran-Sulfate-Sodium-Induced Colitis in Mice via T-Cell Receptor Pathway.

Ulcerative colitis (UC) is a chronic immune disease that is difficult to cure. We recently found that chick early amniotic fluid (ceAF) has notable anti-inflammatory and antioxidative properties, through its active components. This study demonstrates the potential of ceAF as a protective agent against UC.

[Early efficacy of local tranexamic acid in reducing postoperative swelling in hallux valgus surgery].

Objective: To evaluate the early efficacy of local application of tranexamic acid on the osteotomy surface during hallux valgus surgery in reducing postoperative occult blood loss and thus postoperative swelling.

Methods: The data of 40 cases with hallux valgus osteotomy admitted to the Department of Foot and Ankle Surgery of Jishuitan Hospital from July 11, 2022 to October 8, 2022, including 5 males and 35 females were retrospectively analyzed. According to the inclusion and exclusion criteria, 32 cases were finally divided into 16 cases in the observation group (application of tranexamic acid) and 16 cases in the control group (no application of tranexamic acid).

Se-methylselenocysteine inhibits inflammatory response in an LPS-stimulated chicken HD11 macrophage-like cell model through the NFKB2 pathway.

Among the various sources of selenium supplementations, the Se-methylselenocysteine (SeMC) is a natural organic selenium compound that has been demonstrated to have multiple advantages in terms of metabolism efficiency and biosafety in animals. Nevertheless, the genome-wide impact of SeMC on gene transcription remains to be elucidated. In this study, we employed an LPS-stimulated chicken HD11 macrophage-like cell model to identify the principal transcription factors involved in transcriptome regulation responsible for SeMC treatment.

Modular organization of enhancer network provides transcriptional robustness in mammalian development.

Enhancer clusters, pivotal in mammalian development and diseases, can organize as enhancer networks to control cell identity and disease genes; however, the underlying mechanism remains largely unexplored. Here, we introduce eNet 2.0, a comprehensive tool for enhancer networks analysis during development and diseases based on single-cell chromatin accessibility data.

Unveiling urinary extracellular vesicle mRNA signature for early diagnosis and prognosis of bladder cancer.

Bladder cancer (BC) ranks as one of the most prevalent cancers. Its early diagnosis is clinically essential but remains challenging due to the lack of reliable biomarkers. Extracellular vesicles (EVs) carry abundant biological cargoes from parental cells, rendering them as promising cancer biomarkers.

Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023.

Objective: This study investigated the distribution and changes in pancreatic infections among patients with acute pancreatitis (AP) from 2019 to 2023, while exploring the impact of multidrug-resistant bacterial infections on the prognosis of patients with poor outcomes.

Methods: This study included patients diagnosed with SAP between 2019 and 2023 and collected the demographic and clinical characteristics of all participants. Based on routine clinical microbiological culture results, the distribution and drug resistance of pathogens associated with pancreatic infections were analyzed.

Identification of aberrant plasma vesicles containing AAK1 and CCDC18-AS1 in adolescents with major depressive disorder and preliminary exploration of treatment efficacy.

Background: Major depressive disorder (MDD) during adolescence significantly jeopardizes both mental and physical health. However, the etiology underlying MDD in adolescents remains unclear.

Methods: A total of 74 adolescents with MDD and 40 health controls (HCs) who underwent comprehensive clinical and cognitive assessments were enrolled.

Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence.

Gut microbiota plays a crucial role in the host health in the aging process. However, the mechanisms for how gut microbiota triggers cellular senescence and the consequent impact on human aging remain enigmatic. Here we show that phenylacetylglutamine (PAGln), a metabolite linked to gut microbiota, drives host cellular senescence.