Phase and Orbital Engineering Effectuating Efficient Adsorption and Catalysis toward High-Energy Lithium-Sulfur Batteries.

The delicate construction of electrocatalysts with high catalytic activity is a strategic method to enhance the kinetics of lithium-sulfur batteries (LSBs). Adjusting the local structure of the catalyst is always crucial for understanding the structure-activity relationship between atomic structure and catalyst performance. Here, in situ induction of electron-deficient B enables phase engineering MoC, realizing the transition from hexagonal (h-MoC) to cubic phase (c-B-MoC).

The integrated stress response pathway controls cytokine production in tissue-resident memory CD4 T cells.

Tissue-resident memory T (T) cells are a specialized T cell population that reside in tissues and provide a rapid protective response upon activation. Here, we showed that human and mouse CD4 T cells existed in a poised state and stored messenger RNAs encoding proinflammatory cytokines without protein production. At steady state, cytokine mRNA translation in T cells was suppressed by the integrated stress response (ISR) pathway.

ELF5 gene promotes milk lipid synthesis in goat mammary epithelial cells by transcriptomic analysis.

E74-like factor 5 (ELF5) is an Ets transcription factor of epithelial development, while the function of ELF5 gene in goat milk fat synthesis remains to be elucidated. In goat mammary epithelial cells, we performed RNA sequencing and analyzed differentially expressed genes (DEGs) after ELF5 gene overexpression. ELF5 gene significantly up-regulated the synthesis of triglyceride, total cholesterol, free fatty acid, and lipid droplets.

Niobium Phosphide-Induced Sulfur Cathode Interface with Fast Lithium-Ion Flux Enables Highly Stable Lithium-Sulfur Catalytic Conversion.

Research on the Li-S catalytic chemistry primarily focus on the development of high-performance catalysts and the exploration of their reaction mechanisms, with limited attention given to the impact on the interface at the cathode. Moreover, regulating the Li flux at the cathode interface can enhance LiS conversion kinetics without compromising the intrinsic catalytic activity of catalyst. This work presents a paradigm that employs interface regulation to enhance Li-S battery (LSB) cycling stability.

Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive infections: insights from a tertiary hospital in Northern China.

Background: To compare the risk factors, clinical outcomes, and mortality rates between carbapenem-resistant (CRKP) and carbapenem-sensitive (CSKP) infections.

Methods: A retrospective cohort study was conducted on patients with infections admitted to a tertiary hospital in Zhangjiakou, China. The research period is from January 2021 to December 2022.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice.

Gout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. Recent research has provided evidence of distinct differences in the gut microbiota of patients with gout and hyperuricemia compared to healthy individuals. However, the link between gut microbiota and age-related gout remained underexplored.

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.

As essential micronutrients, metal ions such as iron, manganese, copper, and zinc, are required for a wide range of physiological processes in the brain. However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cuproptosis, cell senescence, or neuroinflammation. These processes have been found to be involved in the pathological mechanisms of neurodegenerative diseases.

Exploring the experiences of cognitive symptoms in Long COVID: a mixed-methods study in the UK.

Objective: To explore the lived experiences and extent of cognitive symptoms in Long COVID (LC) in a UK-based sample.

Design: This study implemented a mixed-methods design. Eight focus groups were conducted to collect qualitative data, and the Framework Analysis was used to reveal the experiences and impact of cognitive symptoms.

The effect of increased vascular afterload measures on flow rate and survival in severe aortic stenosis.

Aims: Although an association between the systemic circulation and transaortic flow rate (TFR) is frequently hypothesized in patients with aortic stenosis (AS), it has not been demonstrated previously. We sought to explore the relationship between blood pressure (BP), vascular afterload measures, clinical history of hypertension, TFR, and survival in patients with severe AS (aortic valve area ≤ 1 cm²).

Methods And Results: We studied 323 patients ≥ 65 years (110 prospective, 213 registry analysis) who underwent transcatheter aortic valve replacement over a 5-year period.

Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model.

Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease (PD), supporting the "body-first" hypothesis. However, there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research.

Intranasal iron administration induces iron deposition, immunoactivation, and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice.

Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function; however, its abnormal accumulation is also implicated in various neurological disorders. The olfactory bulb (OB), an early target in neurodegenerative diseases, acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles. This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate (FAC).

Factors influencing preformed metal crowns and prefabricated zirconia crowns.

Backgound: Preformed metal crowns (PMCs) and zirconia crowns (ZCs) are commonly used for the treatment of primary molar caries. However, there have been no reports on factors influencing parental awareness, willingness to use these treatments, and the associated discomfort after crown placement in children.This study is the first to report factors influencing preformed crowns, providing a reference for the prevention and treatment of deciduous carious teeth.

Effect of PM2.5 air pollution on the global burden of neonatal diarrhea from 1990 to 2019.

The primary risk factor for global disease burden is prolonged exposure to particulate matter (PM) air pollution, which results in health problems and death. However, the global burden of diarrheal diseases attributable to PM2.5 remains unclear.

Exploring key embryonic developmental morphokinetic parameters that affect clinical outcomes during the PGT cycle using time-lapse monitoring systems.

Research Question: Is it possible to predict blastocyst quality, embryo chromosomal ploidy, and clinical pregnancy outcome after single embryo transfer from embryo developmental morphokinetic parameters?

Design: The morphokinetic parameters of 1011 blastocysts from 227 patients undergoing preimplantation genetic testing were examined. Correlations between the morphokinetic parameters and the quality of blastocysts, chromosomal ploidy, and clinical pregnancy outcomes following the transfer of single blastocysts were retrospectively analyzed.

Results: The morphokinetic parameters of embryos in the high-quality blastocyst group were significantly shorter than those in the low-quality blastocyst group (p < 0.

FOXM1-activated IGF2BP3 promotes cell malignant phenotypes and M2 macrophage polarization in hepatocellular carcinoma by inhibiting ferroptosis via stabilizing RRM2 mRNA in an m6A-dependent manner.

Background: Ferroptosis has a crucial role in human carcinogenesis. N6-methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) suppresses ferroptosis of hepatocellular carcinoma (HCC) cells. Here, we examined the effects and molecular determinants of IGF2BP3-mediated ferroptosis on malignant behaviors of HCC cells.

Electrodeposition, microstructure and characterization of high-strength, low-roughness copper foils with polyethylene glycol additives.

Electroplating additives play a key role in enhancing the physical and chemical performances of electrodeposited copper foils. Currently, a lot of research on polyethylene glycol (PEG) additives has been reported on the metallisation interconnections for printed circuit boards (PCBs); however, research on its applications for electrodeposited copper foils is rarely documented. Herein, high-quality copper foils with high tensile strength (433.

Alloying Strategy Regulating Size and Electronic Structure of MoNbSe to Achieve High-Performance Lithium-Sulfur Batteries.

The utilization of catalysts in lithium--sulfur batteries has proven to be an efficacious avenue for enhancing the kinetics of polysulfide conversion. Specially, the size and electronic structure of catalysts play a pivotal role in harnessing the active sites and intrinsic catalysis activity. Outstanding MoSe and NbSe are were selected from 16 universal transition metal selenides based on the proposed binary descriptor.

Targeting lncRNA MALAT1: A Promising Approach to Overcome Metabolic Syndrome.

Metabolic syndrome (MetS) is a collection of metabolic abnormalities including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension. Recently, long noncoding RNAs (lncRNAs) have emerged as pivotal regulators of metabolic balance, influencing the genes associated with MetS. Although the prevalence of insulin resistance is rising, leading to an increased risk of type 2 diabetes mellitus (T2DM) and its vascular complications, there is still a notable gap in understanding the role of lncRNAs in the context of clinical diabetes.

Decreased miR-486-5p is involved in lipopolysaccharide-induced HTR-8/SVneo cell dysfunction by promoting SMAD2 expression.

In Brief: Insufficiency of extravillous trophoblast (EVT) cell invasion is implicated in pregnancy complications. This study reveals the roles of the miR-486-5p/Smad2 pathway in lipopolysaccharide (LPS)-induced EVT dysfunctions and in the pathogenesis of early pregnancy loss (EPL).

Abstract: Placenta-associated pathologies, including EPL and preeclampsia, are characterized by insufficient EVT invasion.

Possible involvement of a MEG3-miR-21-SPRY1-NF-κB feedback loop in spermatogenic cells proliferation, autophagy, and apoptosis.

Non-obstructive azoospermia (NOA) is the most incurable form of male infertility with a complex etiology. Long non-cording RNAs (lncRNAs) were associated with regulating spermatogenesis. Herein, differentially expressed lncRNAs between NOA and control male were screened by RNA-seq analysis.

Expected 8-Week Prenatal vs 12-Week Perinatal Tenofovir Alafenamide Prophylaxis to Prevent Mother-to-Child Transmission of Hepatitis B Virus: A Multicenter, Prospective, Open-Label, Randomized Controlled Trial.

Introduction: The course of maternal antiviral prophylaxis to prevent mother-to-child transmission of hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study.

Methods: In this multicenter, open-label, randomized controlled trial, eligible pregnant women with HBV DNA of 5.3-9.