SS-31 modification alleviates ferroptosis induced by superparamagnetic iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes.

Superparamagnetic iron oxide nanoparticles (SPION) are widely used in cardiovascular applications. However, their potential to induce ferroptosis in myocardial cells post-ischemia-reperfusion hinders clinical adoption. We investigated the mechanisms behind SPION-induced cytotoxicity in myocardial cells and explored whether co-loading SPION with SS-31 (a kind of mitochondrial-targeted antioxidant peptide) could counteract this toxicity.

The mediating effects of parental hope and psychological resilience on social support and decision conflict in children with hypospadias.

Introduction: The most common congenital genital abnormality of the urinary system in infants is hypospadias; its frequency is rising to 0.33 percent globally. Surgical reconstruction is the most effective treatment for hypospadias.

Twist-Net: A multi-modality transfer learning network with the hybrid bilateral encoder for hypopharyngeal cancer segmentation.

Hypopharyngeal cancer (HPC) is a rare disease. Therefore, it is a challenge to automatically segment HPC tumors and metastatic lymph nodes (HPC risk areas) from medical images with the small-scale dataset. Combining low-level details and high-level semantics from feature maps in different scales can improve the accuracy of segmentation.

Construction of a nurses' interpersonal communication knowledge system: A Delphi study.

Background: Effective communication is essential for nursing students to provide safe patient care. Many communication consensuses focus on physician-associated communication rather than nurses' interpersonal communication. However, studies on developing a systematic and comprehensive communication knowledge system for nursing students are scarce.

Basement Membrane Changes of Myofiber and Fibrosis in Sternocleidomastoid Muscle of Congenital Muscular Torticollis.

Objective: To investigate the correlation between the features of basement membranes (BMs) of residual myofibers in the sternocleidomastoid muscle (SCM) and fibrosis of congenital muscular torticollis (CMT) in children, and to evaluate the relationship between BM changes and appearance of CMT.

Materials And Methods: We reviewed the CMT patients from 2017 to 2018 and performed pathological studies. Forty resected specimens were stained by hematoxylin and eosin and Masson collagen staining.

CCS-Net: Cascade Detection Network With the Convolution Kernel Switch Block and Statistics Optimal Anchors Block in Hypopharyngeal Cancer MRI.

Magnetic resonance imaging (MRI) is a common diagnostic method for hypopharyngeal cancer (HPC). It is a challenge to automatically detect HPC tumors and swollen lymph nodes (HPC risk areas) from MRI slices because of the small size and irregular shape of HPC risk areas. Herein, we propose a cascade detection network with Convolution Kernel Switch (CKS) Block and Statistics Optimal Anchors (SOA) Block in HPC MRI (CCS-Net).

Analysis of the directivity of longitudinal waves based on double-fold coil phased EMAT.

Longitudinal critically refracted (LCR) waves have already been widely applied for residual stress characterization. Such waves are usually generated using mode-conversion at the first critical angle of the incident longitudinal wave, which gives waves that then propagate at a dip-angle, and this places energy close to the surface of the specimen. The dip-angle needs to be minimized to improve both velocity measurement and residual stress characterization sensitivity.

2D Heterostructure of Amorphous CoFeB Coating Black Phosphorus Nanosheets with Optimal Oxygen Intermediate Absorption for Improved Electrocatalytic Water Oxidation.

The oxygen evolution reaction (OER) plays a paramount role in a variety of electrochemical energy conversion devices, and the exploration of highly active, stable, and low-cost electrocatalysts is one of the most important topics in this field. The exfoliated black phosphorus (EBP) nanosheet with a two-dimensional (2D) layered structure has high carrier mobility but is limited by excessive oxygen-containing intermediate absorption and fast deterioration in air. We here report the fabrication of nanohybrids of amorphous CoFeB nanosheets on EBP nanosheets (EBP/CoFeB).

In situ growth of Z-scheme CuS/CuSCN heterojunction to passivate surface defects and enhance charge transport.

Copper thiocyanate (CuSCN) has been considered as a promising hole transport material (HTMs), attributing to its inherent stability, low-cost, and suitable energy levels. To make it more attractive in practical applications, the drawbacks of CuSCN in poor charge transport and serious defect recombination are bottlenecks that need to be overcome. In this work, we propose an effective strategy of in-situ decorating CuSCN with copper sulfide quantum dots (CuS QDs), a simple one-step electrochemical deposition process, to solve these issues.

Analysis of the directivity of Longitudinal Critically Refracted (LCR) waves.

The use of ultrasonic longitudinal critically refracted (LCR) waves is one approach used for near surface material characterization. It has been shown to be sensitive to stress and, in general, less sensitive to the effects of the texture of the material. Although the LCR wave is increasingly widely applied, in experiments the factors that influence the formation of the LCR beam are seldom discussed.

Untargeted GC/TOFMS unravel metabolic profiles in cerebrospinal fluid of Chinese people living with HIV.

Background: Metabolic syndrome becomes a focus of clinical cares to people living with HIV (PLHIV) globally. This study aimed to explore the metabolic profiles in cerebrospinal fluid (CSF) of Chinese people living with HIV (PLHIV).

Methods: Cerebrospinal fluid samples from PLHIV and healthy controls were collected from our hospital.

Thalidomide in the treatment of human immunodeficiency virus-negative tuberculous meningitis: A case report.

Introduction: Tuberculous meningitis (TBM) is the most fatal type of tuberculosis in which corticosteroids are added with antitubercular therapy to prevent permanent brain damage. However, this treatment may produce paradoxical reactions. In such cases, thalidomide use might reduce central nervous system inflammation and improve the outcome.

Pharmacologic ascorbate as a pro-drug for hydrogen peroxide release to kill mycobacteria.

Background And Purpose: Tuberculosis is one of the most highly fatal diseases worldwide, and one-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis). A previous study showed that M.

c-Jun regulates the promoter of small subunit hemocyanin gene of Litopenaeus vannamei.

Hemocyanin (HMC) is a respiratory glycoprotein, which also plays multifunctional non-specific innate immune defense functions in shrimp. However, the transcriptional regulatory mechanisms of the hemocyanin gene expression have not been reported. In the present study, we cloned a 4324 bp fragment of small subunit hemocyanin (HMCs) gene of Litopenaeus vannamei including the 5'-flanking region, from upstream 2475 bp to downstream 1849 bp (exon 1-intron 1-exon 2) by genome walking method.

Uniform magnetic targeting of magnetic particles attracted by a new ferromagnetic biological patch.

A new non-toxic ferromagnetic biological patch (MBP) was designed in this paper. The MBP consisted of two external layers that were made of transparent silicone, and an internal layer that was made of a mixture of pure iron powder and silicon rubber. Finite-element analysis showed that the local inhomogeneous magnetic field (MF) around the MBP was generated when MBP was placed in a uniform MF.

Litopenaeus vannamei notch affects lipopolysaccharides induced reactive oxygen species.

Notch signaling pathway was originally discovered in the development stage of drosophila but has recently been found to play essential roles in innate immunity. Most previous studies on Notch have focused on mammals, whereas, in this study, we employed the shrimp Litopenaeus vannamei as a model to study the functions of Notch in invertebrate innate immune system. Our results showed that LvNotch was highly expressed in hemocytes and could be strongly induced by lipopolysaccharides (LPS) injection.

Comparison of acoustoelastic Lamb wave propagation in stressed plates for different measurement orientations.

High order Lamb waves are investigated for the effects of stress on both symmetrical and anti-symmetrical modes in an aluminum plate for wave propagation and load parallel. Data are compared with those for the case of load and measurement axis perpendicular. It is the S mode which exhibits significantly higher sensitivity to stress than other Lamb modes.

Higher order acoustoelastic Lamb wave propagation in stressed plates.

Modeling and experiments are used to investigate Lamb wave propagation in the direction perpendicular to an applied stress. Sensitivity, in terms of changes in velocity, for both symmetrical and anti-symmetrical modes was determined. Codes were developed based on analytical expressions for waves in loaded plates and they were used to give wave dispersion curves.

Aggregation process of paramagnetic particles in fluid in the magnetic field.

Magnetic targeting is a promising therapeutic strategy for localizing systemically delivered magnetic responsive drugs or cells to target tissue, but excessive aggregation of magnetic particles could result in vascular embolization. To analyze the reason for embolization, the attractive process of magnetic particles in magnetic field (MF) was studied in this paper by analyzing the form of the aggregated paramagnetic particles while the particle suspension flowed through a tube, which served as a model of blood vessels. The effects of magnetic flux density and fluid velocity on the formation of aggregated paramagnetic particles were investigated.

Comparison of Magnetic Intensities for Mesenchymal Stem Cell Targeting Therapy on Ischemic Myocardial Repair: High Magnetic Intensity Improves Cell Retention but Has no Additional Functional Benefit.

Magnetic targeting has the potential to enhance the therapeutic effects of stem cells through increasing retention of transplanted cells. To investigate the effects of magnetic targeting intensities on cell transplantation, we performed different magnetic intensities for mesenchymal stem cell (MSC)-targeting therapy in a rat model of ischemia/reperfusion. Rat MSCs labeled with superparamagnetic oxide nanoparticles (SPIOs) were injected into the left ventricular (LV) cavity of rats during a brief aorta and pulmonary artery occlusion.

Magnetic targeting enhances retrograde cell retention in a rat model of myocardial infarction.

Introduction: Retrograde coronary venous infusion is a promising delivery method for cellular cardiomyoplasty. Poor cell retention is the major obstacle to the establishment of this method as the preferred route for cell delivery. Here, we explored whether magnetic targeting could enhance retrograde cell retention in a rat model of myocardial infarction.