Blockade of voltage-sensitive K+ channels increases contractility more in transverse than in longitudinal rat detrusor strips.

Objectives: To investigate the effects of voltage-sensitive K(+) channel blockade on phasic contractions in transverse (TR) and longitudinal (LO) rat detrusor strips. The contractility of LO detrusor strips has been studied more extensively than that of TR ones, with the latter hardly used in experiments. Phasic contractions, regulated by various types of K(+) channels, are present in normal bladders and are more commonly seen in diseased bladders.