177Lu Radiolabeled Polydopamine Decorated with Fibroblast Activation Protein Inhibitor for Locoregional Treatment of Glioma.

Radionuclide therapy is expected to be a powerful tool for glioma treatment. Here, we introduce a novel nuclear nanomedicine based on polydopamine (PDA), incorporating fibroblast activation protein inhibitor (FAPI) and macrocyclic chelator (DOTA) for specific cancer targeting and 177Lu labeling. The synthesized nanoradiopharmaceutical, 177Lu-DOTA-PEG-PDA-FAPI, exhibits good stability in serum, saline and PBS over 5 days.

Deniable ring signature scheme based on the ISRSAC digital signature algorithm.

This article introduces a deniable ring signature scheme within the framework of a ring signature protocol, which allows a member of the ring to assert or deny their role as the signature's originator without the involvement of a trusted third party. Deniable ring signatures find applications in various scenarios where balancing privacy protection with supervised oversight is crucial. In this work, we present a novel deniable ring signature scheme based on the ISRSAC digital signature, tailored for environments with regulatory requirements, empowering regulators to hold malicious signers accountable.

Genome-Wide Identification and Expression Analysis of /s in L.

Pepper ( L.) is a popular vegetable in people's daily lives. During pepper growth, calcium (Ca) is an essential macronutrient, and calcium-transporting ATPase (ACA/ECA) is a vital protein for calcium transport.

Isolation and manipulation of meiotic spindles from mouse oocytes reveals migration regulated by pulling force during asymmetric division.

Spindles are essential for accurate chromosome segregation in all eukaryotic cells. This study presents a novel approach for isolating fresh mammalian spindles from mouse oocytes, establishing it as a valuable model system for a wide range of possible studies. Our method enables the investigation of the physical properties and migration force of meiotic spindles in oocytes.

Construction of Pt─O Sites on Pt Nanoclusters in Silicalite-1 Zeolite for Efficient Catalytic Oxidation of Hydrogen Isotope Gases.

The construction, use, and maintenance of tritium-related equipment will inevitably produce tritium-containing radioactive waste gas, and the production of efficient catalysts for tritium removal remains a difficult problem. Herein, silicalite-1 zeolite with entrapped Pt nanoclusters is skillfully post-oxidized at an appropriate temperature, building highly active Pt─O sites on the nanoclusters to achieve efficient oxidation of hydrogen isotopes at low temperatures. The designed Pt─O sites can directly participate in the oxidation reaction of hydrogen isotopes.

A novel protein corona-induced aggregation-ECL strategy based on poly-l-cys/Cu NCs for detecting microplastics in water.

To address the health risks posed by microplastics (MPs), this work developed a poly-l-cysteine (poly-L-cys)-based electrochemiluminescence (ECL) sensor for detecting MPs in water environments. The porous structure of poly-L-cys film can regulate the generation of copper nanoclusters (Cu NCs) in the pores, effectively limiting the migration and aggregation of nanopaticles. In addition, poly-L-cys film also acted as co-reactant promoters, promoting electron transfer and effectively enhancing ECL signal of Cu NCs.

Exosomes derived from umbilical cord mesenchymal stem cells ameliorate ischemic brain injury in mice by regulating AAK1 via miR-664a-5p.

Objective: To identify the molecular targets of MSC-derived exosomes in treating cerebral ischemia and elucidate their therapeutic mechanisms.

Methods: We utilized a mouse model of middle cerebral artery occlusion (MCAO) and treated mice with umbilical cord mesenchymal stem cells (uc-MSCs) derived exosomes. Proteomic analysis identified AAK1(AP2 associated kinase 1) as a key target protein.

Regulation of AUF1 alternative splicing by hnRNPA1 and SRSF2 modulate the sensitivity of ovarian cancer cells to cisplatin.

Purpose: Clarification of cisplatin resistance may provide new targets for therapy in cisplatin resistant ovarian cancer. The current study aims to explore involvement of isoforms of AU-rich element RNA-binding protein 1 (AUF1) in cisplatin resistance in ovarian cancer.

Methods: The cancer stem cell-like features were analyzed using colony formation assay, tumor sphere formation assay and nude mouse xenograft experiments.

Synthesis of 2-(3,5-Dinitrophenyl)-5-(trinitromethyl)-1,3,4-oxadiazole.

The trinitromethyl group plays a crucial role in the energetic material industry due to its high oxygen balance and energetic properties. This study focuses on the synthesis of dinitrophenyl-substituted trinitromethyl-1,3,4-oxadiazole. The introduction of dinitrophenyl groups to trinitromethyl-1,3,4-oxadiazole aims to improve its stability against heat-induced decomposition, a critical factor in ensuring the safe and reliable performance of energetic materials.