Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models.

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade serous ovarian cancer with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within the tumor and microenvironment.

Mutational Landscape of Ameloblastoma: Analysis of BRAF and Other Key Mutations in Chinese Patients.

Objectives: To investigate the prevalence of BRAF, SMO, KRAS, HRAS, NRAS, FGRF2, and CTNNB1 gene mutations in Chinese ameloblastoma (AM) patients and explore their associations with clinical characteristics.

Materials And Methods: DNA was extracted from 89 formalin-fixed paraffin-embedded AM samples (9 unicystic and 80 conventional). PCR and Sanger sequencing were used to detect mutations, followed by statistical analysis to assess correlations between mutations and clinical variables.

Elevated COMMD1 Contributes to Cardiomyocyte Copper Efflux in Chronic Myocardial Ischemia: Insights From Rhesus Monkey.

Copper deficiency, commonly observed in myocardial infarction, leads to cardiomyocyte loss and cardiac dysfunction, yet the mechanism driving copper efflux remains unclear. To further elucidate the relationship between copper transporters and cardiac copper efflux during chronic myocardial ischemia, a rhesus monkey model was established by performing the permanent ligation of the left anterior descending coronary artery. A dramatic decrease in copper concentration within ischemic cardiomyocytes was observed alongside declining cardiac function.

Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway.

Lycopene is a natural plant extract widely studied for its powerful antioxidant and neuroprotective effects. Emerging evidence suggests that it also possesses potential antidepressant properties. Compared to commonly used clinical antidepressants, lycopene offers higher safety; however, its underlying mechanisms remain unclear.

ITGB4/CD104 mediates zika virus attachment and infection.

Zika virus (ZIKV) infection can result in a birth defect of the brain called microcephaly and other severe fetal brain defects. ZIKV enters the susceptible host cells by endocytosis, which is mediated by the interaction of the envelope (E) glycoprotein with cellular surface receptor molecules. However, the cellular factors that used by the ZIKV to gain access to host cells remains elusive.

Association between life's simple 7 (LS7) and arthritis: the mediating role of body fat percentage (BFP).

Background: Life's Simple 7 (LS7), developed by the American Heart Association, addresses seven key health behaviors and relationship factors. Although LS7 has been studied in relation to various chronic diseases, its association with arthritis remains unclear. This study seeks to investigate the association between LS7 and arthritis, with particular emphasis on the mediating role of body fat percentage (BFP).

Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder.

Background: Major depressive disorder (MDD) is one of the most serious mental disorders affecting adolescents worldwide. Electroconvulsive therapy (ECT) is widely acknowledged as a first-line treatment for severe depression, but the clinical response varies. Neutrophils and platelets are both related to the progression of MDD.

Probe on the pivotal role of green rust in improving the enzymatic activity and facilitating the formation of O in Fenton-like process for degradation of 4-chlorophenol.

Iron-based materials have demonstrated significant efficacy in catalyzing hydrogen peroxide (HO) for the removal of antibiotics from aquatic environments. Green rust (GR), a hybrid valence state iron-based catalyst, was synthesized. By exploiting the catalytic properties of glucose oxidase (GOx) to generate HO from glucose (Glu), a GR-GOx/Glu system for the removal of recalcitrant organic compound 4-chlorophenol (4-CP) was constructed.

Effects of electroconvulsive therapy on inflammatory markers and depressive symptoms in adolescents with major depressive disorder.

Objective: Limited research exists on the use of electroconvulsive therapy (ECT) for adolescents with major depressive disorder (MDD). This study investigates the effects of ECT on inflammatory markers in adolescents aged 13-18 suffering from severe MDD, evaluating its efficacy in modulating cellular inflammatory markers and ameliorating depressive symptoms.

Methods: A cohort of 38 adolescents with severe MDD received standard antidepressant therapy along with 6-8 ECT sessions spanning two weeks.

Extending the Chevrel-type superatoms to the nitrogen family.

Chevrel-type superatoms refer to the ligated transition metal chalcogenide clusters MEL, where the octahedral M is face-capped with cubic chalcogen E (E = S/Se/Te). Most transition metals can form such superatoms and many organic and inorganic ligands can be substituted in solution reactions, which allows these atomic precision species to be easily functionalized and their properties to be tunable. No test was reported for substituting the chalcogens with pnicogens in this class of materials.

Study on an Interpenetrating Artificial SEI for Lithium Metal Anode Modification and Fast Charging Characterization.

Artificial SEI is one of the effective strategies to improve lithium dendrites and suppress side reactions. However, the role of SEI components and distribution on the modification of the lithium metal anode remains unclear. Therefore, in this study, the oxygen-sulfur (O-S) component and its distribution in SEI were modulated by designing experiments, and then the mechanism of its action was deeply investigated.

Carrimycin, as One of the Drugs in Combination Therapy, for the Treatment of Carbapenem-Resistant Infection.

Purpose: Infection with carbapenem-resistant (CRAB) is a tough nut to crack. Carrimycin is a novel recombinant macrolide antibiotic, and has good anti-infection effects in vivo. At present, it is rarely reported for treatment of CRAB infection.

Sequencing-Dependent Impact of Carbon Coating on Microstructure Evolution and Electrochemical Performance of Pre-lithiated SiO Anodes: Enhanced Efficiency and Stability via Pre-Coating Strategy.

Silicon monoxide (SiO) has attracted considerable interest as anode material for lithium-ion batteries (LIBs). However, their poor initial Coulombic efficiency (ICE) and conductivity limit large-scale applications. Prelithiation and carbon-coating are common and effective strategies in industry for enhancing the electrochemical performance of SiO.

High expression of YEATS2 as a predictive factor of poor prognosis in patients with hepatocellular carcinoma.

YEATS domain containing 2 (YEATS2), it may function as a proto-oncogene. This study aims to investigate if YEATS2 correlates with prognosis in hepatocellular carcinoma. The prognostic landscape of YEATS2 and its relationship with expression in hepatocellular carcinoma were deciphered with public databases, RT-qPCR and western-blot in tissue samples.

[Estimation of Near-surface Ozone Concentration in the Beijing-Tianjin-Hebei Region Based on XGBoost-LME Model].

High spatiotemporal resolution data on near-surface ozone concentration distribution is of great significance for monitoring and controlling atmospheric ozone pollution and improving the living environment. Using TROPOMI-L3 NO, HCHO products, and ERA5-land high-resolution data as estimation variables, an XGBoost-LME model was constructed to estimate the near-surface ozone concentration in the Beijing-Tianjin-Hebei Region. The results showed that： ① Through correlation analysis, surface 2 m temperature （T2M）, 2 m dewpoint temperature （D2M）, surface solar radiation downwards （SSRD）, tropospheric formaldehyde （HCHO）, and tropospheric nitrogen dioxide （NO） were important factors affecting the near-surface ozone concentration in the Beijing-Tianjin-Hebei Region.

[Proposal and Analysis of "Ternary" Model of Sensitization for Proton Therapy].

In order to improve the biological effect of proton therapy, the authors first propose a new method of boron-based proton-enhanced radiotherapy in a " ternary " radiotherapy mode, based on the existing sensitizing effect of proton radiotherapy: i.e, Boron-based mediators (B and B) induce the proton-hydrogen-boron fusion reaction of the low-energy protons arriving at the Bragg peak region of the tumor target area (p+B→3α) and thermal neutron capture (B+n→Li(0.84 MeV)+He(1.

Empowering Photovoltaic Panel Anti-Icing: Superhydrophobic Organic Composite Coating with In Situ Photothermal and Transparency.

Solar energy is widely used in photovoltaic power generation as a kind of clean energy. However, the liquid film, frosting, and icing on the photovoltaic module seriously limit the efficiency of photovoltaic power generation. We developed a composite coating (Y6-NanoSH) by combining an in situ photothermal and transparent Y6 organic film with a nanosuperhydrophobic material.

A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation.

The regenerative treatment of infectious vertical bone defects remains difficult and challenging today. Current clinical treatments are limited in their ability to control bacteria and infection, which is unfavorable for new bone formation and calls for a new type of material with excellent osteogenic and antibacterial properties. Here a multifunctional scaffold is synthesized that mimics natural bone nanostructures by incorporating silver nanowires into a hierarchical, intrafibrillar mineralized collagen matrix (IMC/AgNWs), to achieve the therapeutic goals of inhibiting bacterial activity and promoting infectious alveolar bone augmentation in rats and beagle dogs.

[pMBRT: Principles and Design of Advanced Proton Radiotherapy Techniques].

The development history of pMBRT, the biological role of minibeam, the mechanism of minibeam protection of tissues, the generation of minibeam (collimator method and magnetic focusing method), and the analysis of advantages and disadvantages of proton minibeam matrix arrays is introduced with advanced proton minibeam arrays (pMBRT). It is proposed that the combination of proton minibeam arrays and magnetic resonance fields can help to exploit the normal tissue protective function of pMBRT, and improve the precision of proton therapy.